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TranscriptomicsEffect of L1CAM Knockout on Gene Expression in the Cerebellum
Cerebellum from post-natal day 11 L1 knockout mice on the 129Sv background were compared to wild type littermates. The original goal of the study was to determine if there was compensation from other L1 family members or alterations in cell survival or apoptosis. Interestingly no major changes wer...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-13984 | biostudies-arrayexpress
TranscriptomicsIsoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq
To fully understand cell type identity and function in the nervous system there is a need to understand neuronal gene expression at the level of isoform diversity. Here we applied Next Generation Sequencing of the transcriptome (RNA-Seq) to purified sensory neurons and cerebellar granular neurons (C...
ORGANISM(S): Mus musculus 
2012-01-17 | E-GEOD-33343 | biostudies-arrayexpress
TranscriptomicsA chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.
Injury to the central nervous system (CNS) may result in lifelong loss of function due, in part, to the regenerative failure of CNS neurons. Major barriers to regeneration faced by injured CNS neurons include inhibitory proteins derived from myelin and the astroglial scar. Previously, we described...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-34331 | biostudies-arrayexpress
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