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TranscriptomicsGene expression profiling of MDA-MB-468 cells following p53-R273H mutant knock-down
A total of 58 genes were up-regulated (> 1.5 fold-change) while 117 genes were down-regulated Microarray experiments were performed in duplicate as follows: MDA-MB-468 cells were transduced with lentiviral shRNA targeting endogenous p53-R273H mutant (p53si-1)or a non-targeting shRNA (NS). Total RNA ...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-65967 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of MCF-7 cells treated with 6-shogaol
A total of 18 genes were up-regulated and 11 genes were down-regulated > 2-fold following 6-shogaol treatment Microarray experiments were performed in duplicate as follows: MCF-7 cells were treated with 10 uM of 6-shogaol or control vehicle (0.1% DMSO) for 48 h. Total RNA from cells was extracted us...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-36973 | biostudies-arrayexpress
TranscriptomicsGene expression profiles induced by knockdown and overexpression of p63 variants in MCF-10A mammary epithelial cell line
p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates. The p63 transactivating (TA) isoforms contain an amino-terminal exon that encodes a p53-like transactivation domain, whereas ΔN-isoforms lack this domain but contain the common DNA bind...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20286 | biostudies-arrayexpress
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