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TranscriptomicsGenome-wide expression profiling of leprosy and granuloma annulare skin lesions
Here we report the data generated by short-read sequencing of mRNA (polyA) isolated from granuloma annulare and leprosy skin lesions. Our main aim was to identify putative mRNA biomarkers for distinguishing leprosy from other differential diagnoses. Additionally, we also explored the distinction bet...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10318 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin samples from borderline tuberculoid leprosy and lepromatous leprosy patients
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skin lesions from leprosy samples: Divergence of macrophage phagocytic and antimicrobial programs in leprosy
Effective innate immunity against many microbial pathogens requires macrophage programs that upregulate phagocytosis and direct antimicrobial pathways, two functions generally assumed to be coordinately regulated. Here the regulation of these key functions was investigated in human blood-derived ma...
ORGANISM(S): Homo sapiens 
2009-10-30 | E-GEOD-17763 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics data of leprosy patients with type 1 reaction
Not available
ORGANISM(S): Homo sapiens 
ST000882 | MetabolomicsWorkbench
MetabolomicsTargeted metabolomics data of leprosy patients with type 1 reaction
Not available
ORGANISM(S): Homo sapiens 
ST000881 | MetabolomicsWorkbench
TranscriptomicsmiRNA expression profile in leprosy skin biopsy specimens
Skin biopsy specimens of skin lesions were profiled for miRNA expression. In this study, we indentified miRNA species that were differentially expressed in the skin lesions of either the lepromatous or tuberculoid forms of leprosy. One miRNA species, hsa-mir-21, found in the lepromatous lesions was...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-33192 | biostudies-arrayexpress
TranscriptomicsGenome-wide screening of mRNA expression in leprosy patients
In this study, a comprehensive assessment of human mRNA was performed on leprosy skin lesions using DNA chip microarrays, which included the entire spectrum of the disease along with its reactional states. Sixty-six samples from leprotic lesions (10TT, 10BT, 10BB, 10BL, 4LL, 14R1, and 10R2) and nine...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-74481 | biostudies-arrayexpress
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
TranscriptomicsGenomewide expression profiling of multibacillary leprosy lesions before and after multi-drug therapy (MDT)
[Aim] To characterize the transcriptomic changes in skin lesions of lepromatous leprosy patients before and after multidrug therapy (MDT). Likewise, not all patients improve their bacillary index after MDT. Thus, the further analysis aims to compare patients who responded or did not to MDT and ident...
ORGANISM(S): Homo sapiens 
2022-04-10 | E-MTAB-11605 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in Human leprosy patients
Leprosy is classified from paucibacillary leprosy (TT and BT) to multibacillary leprosy (BB, BL, and LL). In our study, we focus on selecting or classfying the significant genes to discriminate between paucibacillary and multibacillary group and the important genes to distinguish between blood and ...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-24280 | biostudies-arrayexpress
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