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GenomicsCerebrospinal fluid microRNA profile in leptomeningeal metastasis patients [LM vs non-LM]
Cerebrospinal fluid microRNA profile in leptomeningeal metastasis patients [LM vs non-LM]
PRJNA515502 | ENA
GenomicsPhenotypic states of leptomeningeal metastasis
Phenotypic states of leptomeningeal metastasis
PRJNA564289 | ENA
GenomicsCerebrospinal fluid microRNA profile in leptomeningeal metastasis patients [LM vs non-LM]
This study aimed to identify specific CSF miRNAs for diagnosing and monitoring leptomeningeal metastasis with lung adenocarcinoma. In discovery phase, we performed miRNA microarray analysis in CSF samples from leptomeningeal metastasis patients and non-leptomeningeal metastasis controls.
ORGANISM(S): Homo sapiens 
2020-02-26 | GSE125191 | GEO
GenomicsSingle-cell atlas of human leptomeningeal metastasis
Single-cell atlas of human leptomeningeal metastasis
PRJNA633130 | ENA
TranscriptomicsPhenotypic states of leptomeningeal metastasis
Leptomeningeal metastasis (LM), or spread of cancer cells into the cerebrospinal fluid, is characterized by a rapid onset of debilitating neurological symptoms and markedly bleak prognosis. The lack of reproducible in vitro and in vivo models has prevented development of novel, LM-specific therapies...
ORGANISM(S): Homo sapiens 
2020-01-21 | GSE137020 | GEO
TranscriptomicsRNA profiling of CSF resident macrophages and monocyte-macrophages from leptomeningeal metastasis mice
We investigated the functional effect of dura-derived leptomeningeal matastasis (LM)-associated macrophages (dLAMs) on the cerebrospinal fluid (CSF) niche during LM outgrowth. Using lung cancer leptomeningeal metastasis models of Cx3cr1CreER:mTmG mice with tamoxifen administration, we achieved dLAMs...
ORGANISM(S): Mus musculus 
2024-07-24 | GSE267325 | GEO
GenomicsSingle-cell atlas of dura cells from non-tumor or leptomeningeal metastasis mice
Single-cell atlas of dura cells from non-tumor or leptomeningeal metastasis mice
PRJNA1111058 | ENA
ProteomicsDesign and development of nanoproteomics strategies for biomarker identification in cerebrospinal fluid of leptomeningeal disease, using as model lymphoma non-Hodgkin B.
The early diagnosis of leptomeningeal disease is a challenge because it is an asymptomatic pathology in the early stages. Hence, it is highly relevant to identify a panel of biomarkers to help in the diagnosis and/or prognostic. For this purpose, we have explored a multipronged proteomics approaches...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026016 | Pride
Cerebrospinal fluid (csf) Leptomeningeal metastasis (lm) Protein microarrays Protein-based biomarker. Lc-ms/ms 
TranscriptomicsSingle-cell atlas of dura cells from non-tumor or leptomeningeal metastasis mice
We performed scRNA-seq on the cells isolated from the dura mater in non-tumor control mice and leptomeningeal metastasis (LM) mice with LLC-LeptoM cell inoculation for 7 or 12 days.
ORGANISM(S): Mus musculus 
2024-07-24 | GSE267322 | GEO
GenomicsRNA profiling of CSF resident macrophages and monocyte-macrophages from leptomeningeal metastasis mice
RNA profiling of CSF resident macrophages and monocyte-macrophages from leptomeningeal metastasis mice
PRJNA1111061 | ENA
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