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TranscriptomicsCytosolic Phospholipase A2M-NM-1 and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation
The role of Group IVA cytosolic phospholipase A2 (cPLA2M-NM-1) activation in regulating macrophage transcriptional responses to Candida albicans infection was investigated. cPLA2M-NM-1 releases arachidonic acid for the production of eicosanoids. In mouse resident peritoneal macrophages, prostacycli...
ORGANISM(S): Mus musculus 
2013-05-02 | E-GEOD-46533 | biostudies-arrayexpress
TranscriptomicsInferring transcriptional and microRNA-mediated regulatory programs in glioblastoma
Large-scale cancer genomics projects are profiling hundreds of tumors at multiple molecular layers, including copy number, mRNA and miRNA expression, but the mechanistic relationships between these layers are often excluded from computational models. We developed a supervised learning framework for...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32876 | biostudies-arrayexpress
UnknownPathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL--CALGB 150007/150012, ACRIN 6657.
Not available
S-EPMC3434983 | biostudies-literature
TranscriptomicsMemory of inflammation in regulatory T cells
Transcriptome and epigenome of Treg and effector T cells in various activation states. RNA-seq, ATAC-seq, and histone modification ChIP-seq of sorted cell populations
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-83315 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of allelic series of miR-17~92 mutant embryos.
We report the generation of an allelic series of miR-17~92 mutant mice, each carrying the targeted deletion of specific miRNA families encoded by the cluster. We integrate the phenotypic characterization of these strains with RNA-seq analysis showing the consequences of selective miRNA inactivation ...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-63813 | biostudies-arrayexpress
TranscriptomicsTherapeutic globin expression in thalassemia patient induced pluripotent stem cells from genomic safe harbors
The advent of human induced pluripotent stem (iPS) cells enables for the first time the derivation of unlimited numbers of patient-specific stem cells and holds great promise for regenerative medicine. However, realizing the full potential of iPS cells requires robust, precise and safe strategies fo...
ORGANISM(S): Homo sapiens 
2010-10-26 | E-GEOD-24901 | biostudies-arrayexpress
TranscriptomicsEvaluation of methods for modeling transcription factor sequence specificity
Genomic analyses often involve scanning for potential transcription-factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed to model and learn a protein’s binding specificity by representing sequence motifs, including the gaps a...
ORGANISM(S): synthetic construct 
2012-12-13 | E-GEOD-42864 | biostudies-arrayexpress
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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