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ProteomicsThe NuRD complex is required for Thpok-mediated CD4+ T cell development
This data represent characterization of the interactome of murine Thpok. A version of Thpok (Thpok-Bio) subject to biotinylation in vivo by the BirA biotin ligase was used; to assess Thpok interactions in primary cells, Thpok-Bio was retrovirally expressed in in vitro activated CD4+ T cells from Thp...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000088126 | MassIVE
MetabolomicsMaHPIC Experiment E03 - Quantitative Metabolomics of Macaca mulatta infected with Plasmodium coatneyi Hackeri strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute, recrudescent, and chronic infections
MaHPIC Experimental Description:
Malaria-naive male rhesus macaques (Macaca mulatta), approximately four years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles
2018-09-05 | MTBLS691 | MetaboLights
MetabolomicsMaHPIC Experiment 07A and 07B: Quantitative Metabolomics from Macaca fascicularis infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
E07 was originally planned and implemented prior to E06. The E07 cohort was inoculated with freshly dissected P. knowlesi sporozoites on 11/01/16. However, for unexplained reasons blood-stage parasitemias did not occur. Consequently, the E07 cohort was reinoculated with cryopreserved P. kn...
2019-01-11 | MTBLS822 | MetaboLights
TranscriptomicsThe codon 72 polymorphism of p53 regulates interactions with NF-κB and transactivation of genes involoved in immunity and inflamation
A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either proline(P72) or arginine(R72). These two variants might possess altered biological function which influences p53’s transcriptional, senescence and apoptotic functions. We found that P72 has increased apoptosis when com...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26851 | biostudies-arrayexpress
TranscriptomicsEvolutionary insights into scleractinian corals using comparative genomic hybridizations
Background Coral reefs belong to the most ecologically and economically important ecosystems on our planet. Yet, they are under steady decline worldwide due to rising sea surface temperatures, disease, and pollution. Understanding the molecular impact of these stressors on different coral species is...
ORGANISM(S): Acropora cervicornis 
2012-11-22 | E-GEOD-37279 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for chronic lymphocytic leukemia samples
Although in 80% of CLL cases that require therapy is possible to achieve a complete remission using a combination of fludarabine, anti-CD20 in conjunction with cyclophosphamide and/or mitoxantrone, 20% of patients do not achieve disease control with this conventional approach. The main reason of c...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-51711 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis wild type and hfr1/sics1 knock-out mutant seedlings exposed to low R/FR light
Aim of the experiment is the identification of genes differentially regulated in hfr1/sics1 seedlings relative to wild type after prolonged exposure to low R/FR. To this end, gene expression changes were analysed in Arabidopsis wild-type and hfr1/sics1 knock-out mutant seedlings exposed to low R/FR ...
ORGANISM(S): Arabidopsis thaliana 
2006-03-01 | E-MEXP-444 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis thaliana seedlings after exposure to low R/FR light for a short and a long period of time
Aim of the experiment is the identification of regulatory genes rapidly induced by low R/FR and still up-regulated after prolonged exposure to FR-rich light. To this end, gene expression changes were analysed in Arabidopsis thaliana seedlings after exposure to low R/FR light for a short and a long p...
ORGANISM(S): Arabidopsis thaliana 
2006-03-01 | E-MEXP-443 | biostudies-arrayexpress
TranscriptomicsEffects of aneuploidy on cellular physiology and cell division in haploid yeast.
Aneuploidy is a condition frequently found in tumor cells but how it affects cellular physiology is not known. We have characterized one aspect of aneuploidy, the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of ...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-17 | E-GEOD-7812 | biostudies-arrayexpress
MetabolomicsMetabolomics analysis of the toxic effects of the production of lycopene and its precursors
Using cells as microbial factories enables highly specific production of chemicals with many advantages over chemical syntheses. A number of exciting new applications of this approach are in the area of precision metabolic engineering, which focuses on improving the specificity of target production....
2021-02-11 | MTBLS642 | MetaboLights
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