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MetabolomicsA Generalized Strategy to Kill Leukemic Cells by Targeting the Regulatory Systems Governing Mitochondrial Membrane Potential
Targeting mitochondria emerges as a promising anti-leukemia strategy, yet selective mitochondrial disruption remains challenging. Here, we identified elevated mitochondrial membrane potential (MMP) as a hallmark of leukemic transformation and chemotherapy-resistant cells, prompting screening for MMP...
2025-07-11 | MTBLS12596 | MetaboLights
TranscriptomicsRescue of murine Gata1s mutant M7 leukemic cells by full-length Gata1
In this project, we studied a mouse model of human Down Syndrome (DS) megakaryocytic leukemia involving mutations in the GATA1 transcription factor (called GATA1s mutation). The model was generated through retroviral insertional mutagenesis in Gata1s mutant fetal liver progenitors. In this study, we...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-16676 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pre-leukemic stem cells and leukemic stem cells
The molecular pathways mediating unlimited self-renewal and alleged drug resistant properties that are believed to be key for maintenance and re-initiation of leukemia during relapse are largely unexplored area. To gain further insights into the potential pathways responsible for the conversion and...
ORGANISM(S): Mus musculus 
2011-03-12 | E-MEXP-2618 | biostudies-arrayexpress
GenomicsGene expression in murine leukemic B cells treated with leukemic extracellular vesicles
Gene expression in murine leukemic B cells treated with leukemic extracellular vesicles
PRJNA789946 | ENA
ProteomicsTunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells
Intercellular communication within the bone marrow niche significantly influences leukemogenesis and the sensitivity of leukemic cells to therapy. However, the landscape of possible cell-cell interactions is still incomplete. Tunneling nanotubes (TNTs) are a novel mode of intercellular cross-talk. T...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD011013 | Pride
Leukemic cells Silac Human Nanotubues 
TranscriptomicsExpression data from Ezh2-null leukemic cells
The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through tra...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-33808 | biostudies-arrayexpress
GenomicsRIBO-seq analysis of YTHDF2-deficient pre-leukemic cells and control pre-leukemic cells
RIBO-seq analysis of YTHDF2-deficient pre-leukemic cells and control pre-leukemic cells
PRJEB31750 | ENA
TranscriptomicsRNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates Fasudil as an anti-leukemic drug.
Acute myeloid leukemia (AML) is characterized by a marked genetic heterogeneity, which complicates the development of novel therapeutics. The delineation of pathways essential within the patient-individual mutational background might overcome this limitation and facilitate personalized treatment. We...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68925 | biostudies-arrayexpress
ProteomicsGRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Internal tandem duplications in the tyrosine kinase receptor FLT3 (FLT3-ITD) are among the most common lesions in acute myeloid leukemia (AML) and there exists a need for new forms of treatment. Using ex vivo drug sensitivity screening, we found that FLT3-ITD+ patient cells are particularly sensitiv...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD009423 | Pride
Leukemic stem cells Hsp90 Flt3 Er stress Acute myeloid leukemia 
TranscriptomicsInteraction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cells
Chronic lymphocytic leukemic B cells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highlighting molecular networks involved in this cellular crosstalk. We co-cultured purified CLL cells on ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-28787 | biostudies-arrayexpress
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