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TranscriptomicsTranscription profiling of mouse pre-leukemic stem cells and leukemic stem cells
The molecular pathways mediating unlimited self-renewal and alleged drug resistant properties that are believed to be key for maintenance and re-initiation of leukemia during relapse are largely unexplored area. To gain further insights into the potential pathways responsible for the conversion and...
ORGANISM(S): Mus musculus 
2011-03-12 | E-MEXP-2618 | biostudies-arrayexpress
TranscriptomicsABT-737 treatment induces regulation and activation of pathways implicated in cell survival, proliferation and stem cells in treated AML mice survival, proliferation and stem cells in treated AML mice
Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow blast infiltration. Using a transgenic mouse model, MRP8[NRASD12/hBCL-2], in which the NRAS:BCL-2 complex at the mitochondria induces MDS progressing to AML with dysplastic featur...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-48601 | biostudies-arrayexpress
TranscriptomicsRunx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67609 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates Fasudil as an anti-leukemic drug.
Acute myeloid leukemia (AML) is characterized by a marked genetic heterogeneity, which complicates the development of novel therapeutics. The delineation of pathways essential within the patient-individual mutational background might overcome this limitation and facilitate personalized treatment. We...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68925 | biostudies-arrayexpress
ProteomicsImmune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
Persistent therapy-resistant leukemic progenitor cells (LPC) are a main cause of disease relapse and recurrence in acute myeloid leukemia (AML). Specific LPC-targeting therapies may thus improve treatment outcome of AML patients. We demonstrate that LPCs present human leukocyte antigen (HLA)-restric...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038691 | Pride
Mass spectrometry Acute myeloid leukemia Immunotherapy Immunopeptidomics Leukemic progenitor cells Hla peptides 
GenomicsA cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells
A cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells
PRJNA646386 | ENA
TranscriptomicsMicroarray analysis of YTHDF2-deficient leukemic stem cells
YTHDF2 is overexpressed in a broad spectrum of human acute myeloid leukemias (AML). To study the role of YTHDF2 in leukemia, total RNA from Ythdf2CKO (n=4) and Ythdf2CTL (n=4) leukemic stem cells were used for Affymetrix global gene expression analysis.
ORGANISM(S): Mus musculus 
2019-04-05 | E-MTAB-7782 | biostudies-arrayexpress
TranscriptomicsExpression data from Ezh2-null leukemic cells
The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through tra...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-33808 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hematopoietic stem cells in the preleukemic phase from wiltype mice and mice deficient in transcription factor PU.1 to identify transcriptional changes preceding malignant transformation
Knockdown of the transcription factor PU.1 (Spi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of PU.1 knockdown hematopoietic stem cells (HSC) in the preleukemic phase by linear amplification and genome-wide array analysis to identify transcriptional changes precedin...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5654 | biostudies-arrayexpress
UnknownMitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2.
Not available
S-EPMC4446344 | biostudies-literature
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