Leukemic stem cell

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Transcriptomics (3058)
Unknown (1296)
Genomics (1289)
Proteomics (46)
Other (21)
Methylation profiling (9)
Models (4)
Genomic (3)
Metabolomics (1)

Organisms

Homo sapiens (1159)
Mus musculus (892)
Drosophila melanogaster (226)
Arabidopsis thaliana (224)
Caenorhabditis elegans (180)
Saccharomyces cerevisiae (115)
Rattus norvegicus (65)
Escherichia coli (49)
Schizosaccharomyces pombe (37)
Candida albicans (32)
Rhizobium leguminosarum (29)
Streptomyces coelicolor (29)
Escherichia coli str. K-12 substr. MG1655 (23)
Bacillus subtilis (19)
Triticum aestivum (15)
Danio rerio (15)
Sinorhizobium meliloti (14)
Bifidobacterium breve UCC2003 (13)
Pseudomonas aeruginosa (13)
Gallus gallus (13)
Listeria monocytogenes (12)
Staphylococcus aureus (12)
Halobacterium salinarum (11)
Streptococcus agalactiae (11)
Zea mays (11)
Cryptococcus neoformans (11)
Salmonella enterica subsp. enterica serovar Typhimurium (10)
Saccharomyces cerevisiae S288C (9)
Salmo salar (9)
Solanum tuberosum (9)

Organisms

Homo sapiens (283)
Mus musculus (218)
Mus musculus musculus (1)
human blood metagenome (1)
Danio rerio (1)

Repository

biostudies-arrayexpress (3401)
ENA (561)
geo (405)
EGA (35)
pride (35)
MassIVE (5)
dbGaP (3)
BioModels (2)
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jPOST (1)
MetaboLights (1)
PeptideAtlas (1)

Tissue

Bone marrow (11)
Blood (7)
Blood cell (7)
Cell culture (7)
Leukocyte (5)
B cell (2)
Primary cell (2)
Stem cell (2)
Cervix epithelium (1)
Epithelial cell of cervix (1)
HeLa cell (1)
Hematopoietic stem cell (1)
MOLM-14 cell (1)
MOLM-16 cell (1)
MV-4-11 cell (1)
Monocyte (1)
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Permanent cell line cell (1)
Spleen (1)
T cell (1)
TEX cell (1)

Disease

Normal (22)
Acute myeloid leukemia (8)
Adenocarcinoma (4)
Breast cancer (3)
Chronic myeloid leukemia (3)
Infiltrating ductal carcinoma (2)
Primary tumor (2)
Breast adenocarcinoma (2)
Rheumatoid arthritis (2)
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Acute Myeloid Leukemia (2)
Acute promyelocytic leukemia (2)
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Neuroblastoma (2)
CLL (1)
Unspecified peripheral T-cell lymphoma (1)
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Not applicable (1)
Colon cancer Dukes C (1)
Post-stasis (1)
Unclassified carcinoid (1)
No lesions (1)
Challenged with Pieris rapae larvae (1)
Precursor T lymphoblastic leukemia (1)
Acute Lymphoblastic Leukaemia (1)

Technology Type

Mass Spectrometry (35)
Shotgun proteomics (14)
Affinity purification coupled with mass spectrometry proteomics (9)
Bottom-up proteomics (9)
Top-down proteomics (3)
Illumina HiSeq 2000 (2)
ILLUMINA, Illumina HiSeq 1000 (1)
ILLUMINA, NextSeq 500 (1)
Illumina HiSeq 2500, ILLUMINA (1)
Mass spectrometry (1)
Data-dependent acquisition (1)
Data-independent acquisition (1)
Gel-based experiment (1)
Proteogenomics (1)
SWATH MS (1)

Instrument Platform

NextSeq 500 (102)
Illumina HiSeq 2000 (84)
Illumina HiSeq 2500 (64)
Illumina NovaSeq 6000 (48)
Illumina HiSeq 4000 (47)
NextSeq 550 (39)
Illumina MiSeq (27)
Axon GenePix 4000B scanning hardware (20)
GenePix 4000A [Axon Instruments] (13)
GenePix 4000B [Axon Instruments] (13)
Illumina Genome Analyzer II (10)
Scanning hardware (10)
Illumina HiSeq 1500 (10)
ScanArray 4000 [PerkinElmer] (9)
ArrayWoRx Biochip Reader [Applied Precision] (8)
Axon- GenePix4000B (7)
ScanArray scanning hardware (6)
Illumina Genome Analyzer IIx (6)
Microcentrifuge (5)
G2565BA DNA microarray scanner [Agilent] (5)
NextSeq 2000 (5)
Illumina HiSeq 3000 (5)
Ultracentrifuge (4)
AB SOLiD 4 System (4)
ScanArray Lite [PerkinElmer] (4)
GenePix Professional 4200A [Axon Instruments] (4)
G2565AA DNA microarray scanner [Agilent] (4)
Spectronic Helios Alpha UV-Vis spectrophotometer (4)
Generation III Array Scanner [Amersham] (4)
ScanArray Express HT [PerkinElmer] (4)

Publication Date

2013 (425)
2010 (396)
2015 (344)
2014 (311)
2012 (309)
2011 (280)
2016 (235)
2008 (205)
2022 (157)
2009 (130)
2007 (117)
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2005 (98)
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2020 (88)
2006 (86)
2019 (82)
2018 (80)
2024 (76)
2025 (69)
2026 (60)
2017 (57)
2004 (39)
2003 (14)
2002 (1)

UNIPROT ID/AC

Q12337 (1)
R0020C (1)

Metabolite Name

Unkown (1)

IsPrivate

False (2)

First Public Date

2022 (78)
2025 (67)
2026 (66)
2024 (63)
2023 (56)
2014 (54)
2019 (32)
2020 (31)
2021 (30)
2018 (25)
2015 (25)
2017 (16)
2016 (10)
2013 (8)

Modelling Approach

Ordinary differential equation model (2)

Study type

Transcription profiling by array (1544)
ChIP-seq (531)
RNA-seq of coding RNA (326)
ChIP-chip by tiling array (251)
Other (97)
ChIP-chip by array (95)
Methylation profiling by array (69)
Comparative genomic hybridization by array (68)
Methylation profiling by high throughput sequencing (50)
DNA-seq (40)
RNA-seq of non coding RNA (36)
Transcription profiling by tiling array (26)
Cell line - High-throughput sequencing (21)
ATAC-seq (21)
RNA-seq of coding RNA from single cells (19)
Unknown experiment type (18)
High-throughput sequencing (17)
MicroRNA profiling by array (13)
Genotyping by array (11)
RIP-seq (11)
Animal - High-throughput sequencing (10)
RNA-seq of total RNA (9)
Hi-C (8)
Ribo-seq (8)
CUT&RUN (8)
Animal - Single-cell sequencing (7)
Translation profiling (6)
RNAi profiling by array (6)
Human - High-throughput sequencing (5)
Transcription profiling by RT-PCR (5)

Release Date

2013 (456)
2010 (407)
2015 (379)
2014 (340)
2012 (336)
2016 (303)
2011 (292)
2022 (211)
2008 (210)
2021 (203)
2023 (179)
2020 (166)
2019 (158)
2018 (158)
2017 (140)
2009 (135)
2007 (124)
2025 (120)
2024 (112)
2005 (104)
2006 (87)
2004 (40)
2026 (23)
2003 (14)

Lab affiliation

Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0379 Oslo, Norway (2)
Functional Proteomics, ICR (2)
Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva, and Swiss Cancer Center Leman, Geneva, Switzerland (2)
1 Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada 2 Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A5, Canada (1)
1. Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom. 2. Department of Haematology, University of Cambridge, Cambridge, United Kingdom. 3.6. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom. (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA 3Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)
1The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark; 2Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark; 3Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Denmark (1)
Cell and Chemical Biology Leiden University Medical Center The Netherlands (1)
Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London (1)
Department for Molecular Systems Biology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany (1)
Department of Biochemistry and Biomedical Sciences McMaster University (1)
Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Vico L. De Crecchio 7, 80138 Napoli, IT (1)
Department of Chemistry, University of Rochester, United States (1)
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China (1)
Department of Internal Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany (1)
Department of Laboratory Medicine, Lund University, Sweden (1)
Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, 38105 USA (1)
Department of Proteomics and Signal Transduction MaxPlanck Institute of Biochemistry (1)
Department of precious medicine, University of Campania "L.Vanvitelli", vico L. de Crecchio 8, Naples, Italy (1)
Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, Lund, Sweden (1)
Experimental Hematology, University Medical Center Groningen, The Netherlands (1)
Experimental Hematology, University Medical Center Groningen, University of Groningen, The Netherlands (1)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (1)
Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology (1)
Marseille Proteomics, CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes (1)
Pablo Menéndez, ICREA Research Professor Stem cell biology, developmental leukemia & immunotherapy Lab Josep Carreras Leukaemia Research Institute Associate Professor - School of Medicine - University of Barcelona Carrer casanova 143. Barcelona 08036. Spain Tel. (+34) 932414287 (1)
Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia (1)
Professor for Stem Cell Aging Faculty of Medicine Friedrich-Schiller-University Jena Erlanger Allee, 07747 Jena; Germany (1)
Professor of Pediatrics Children’s Hospital of Philadelphia 3615 Civic Center Blvd Philadelphia, PA 19104 (1)
Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University BMC B12, 22184 Lund, Sweden (1)

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Transcription profiling of mouse pre-leukemic stem cells and leukemic stem cells

The molecular pathways mediating unlimited self-renewal and alleged drug resistant properties that are believed to be key for maintenance and re-initiation of leukemia during relapse are largely unexplored area. To gain further insights into the potential pathways responsible for the conversion and...

ORGANISM(S): Mus musculus

2011-03-12 | E-MEXP-2618 | biostudies-arrayexpress

CDK6 as key regulator of hematopoietic and leukemic stem cell activation.

The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (HSCs and LSCs) that exceeds its function as cell-cycle regulator. Although hematopoiesis appears regular under s...

ORGANISM(S): Mus musculus

2015-02-20 | E-GEOD-62012 | biostudies-arrayexpress

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status.

Not available

S-EPMC10568939 | biostudies-literature

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.

Not available

S-EPMC5508733 | biostudies-literature

In Vivo Profiling of Leukemic Stem Cell Fitness

PRJNA497107 | ENA

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

Internal tandem duplications in the tyrosine kinase receptor FLT3 (FLT3-ITD) are among the most common lesions in acute myeloid leukemia (AML) and there exists a need for new forms of treatment. Using ex vivo drug sensitivity screening, we found that FLT3-ITD+ patient cells are particularly sensitiv...

ORGANISM(S): Homo sapiens (Human)

2020-09-02 | PXD009423 | Pride

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Not available

S-EPMC7921413 | biostudies-literature

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

Not available

S-EPMC3769504 | biostudies-literature

Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding.

Not available

S-EPMC4297865 | biostudies-literature

Transcription profiling of hematopoietic stem cell aging

Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties...

ORGANISM(S): Mus musculus

2005-08-16 | E-SMDB-3450 | biostudies-arrayexpress

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5749 Results

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