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TranscriptomicsEffects of CEBPA isoform expression on NB4 cells
Here we investigated the effects of CEBPA transcription factor expression on myeloid NB4 cells. The sequence of rat CEBPA was C-terminally fused to a promiscuous biotin ligase tag (BirA*) and NB4 cell lines were engineered to express the fusion protein under the control of a doxycycline inducible p...
ORGANISM(S): Homo sapiens 
2021-06-26 | E-MTAB-9947 | biostudies-arrayexpress
TranscriptomicsGene expression changes associated with progression of Irf8M-bM-^@M-^S/M-bM-^@M-^S CML-like disease into blast crisis after M-NM-2-catenin activation
Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics, we observed that compound constitutive activation of M-NM-2-catenin and deletion of Irf8 results in progression of CML-like disease into fatal bla...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-49054 | biostudies-arrayexpress
TranscriptomicsDeregulation of the endogenous C/EBPM-NM-2 LIP isoform predisposes to tumorigenesis
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription factor CCAAT enhancer binding protein beta (C/EBPM-NM-2) are expressed from a single intronless Cebpb gene by alternative translation initiation. Isoform expression is sensitive to mammalian target of ...
ORGANISM(S): Mus musculus 
2014-12-16 | E-GEOD-53770 | biostudies-arrayexpress
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