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TranscriptomicsGene expression profiling of histone deacetylase inhibition in epithelioid sarcoma
Epithelioid Sarcoma (ES) is a rare neoplasm uniquely comprised of cells exhibiting both mesenchymal and epithelial features. Having propensity for local and distant recurrence, it can pose a diagnostic dilemma secondary to pathologic complexity. Patients have dismal prognosis due to lack of effectiv...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-66800 | biostudies-arrayexpress
TranscriptomicsMicroRNAs differentially expressed in liposarcoma
We performed expression profiling of microRNAs comparing liposarcomas (n=17) with normal fat pad (n=8). We found 35 miRNAs differentially expression (P<0.0001, fold>1.5), including mir-155. We performed expression profiling of microRNAs comparing liposarcomas with normal fat pad.
ORGANISM(S): Homo sapiens 
2012-03-22 | E-GEOD-31045 | biostudies-arrayexpress
TranscriptomicsUndifferentiated Pleomorphic Sarcoma Model
Analysis of undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma-like tumors from LSL-KrasG12D, p53Fl/Fl mouse model of soft tissue sarcoma. Murine soft tissue sarcomas (n = 17) were compared to normal muscle (n = 4). Tumors were isolated surgically from soft tissue sarcomas generate...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-16779 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles of EZH2 activation
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-47476 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of EZH2 knockdown
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-46904 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of the MPNST
Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. By characterizing recurrent gene copy number aberrations, we gain insight into the most altered pathways with the purpose of scanning possible therapeutic targets. We conducted a microarray...
ORGANISM(S): Homo sapiens 
2011-11-26 | E-GEOD-33881 | biostudies-arrayexpress
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