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TranscriptomicsExpression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls
Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their l...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-21606 | biostudies-arrayexpress
TranscriptomicsHematopoietic cell differentiation is required for initiation of acute myeloid leukemia
Leukemia initiating cells (LICs) of acute myeloid leukemia (AML) may arise from self-renewing hematopoietic stem cells (HSCs) and from committed progenitors. However, it remains unclear how leukemia-associated oncogenes instruct LIC formation from cells of different origins and if differentiation al...
ORGANISM(S): Mus musculus 
2014-09-17 | E-GEOD-61468 | biostudies-arrayexpress
TranscriptomicsHematopoietic cell differentiation is required for initiation of acute myeloid leukemia [Microarray expression]
Leukemia initiating cells (LICs) of acute myeloid leukemia (AML) may arise from self-renewing hematopoietic stem cells (HSCs) and from committed progenitors. However, it remains unclear how leukemia-associated oncogenes instruct LIC formation from cells of different origins and if differentiation al...
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-71687 | biostudies-arrayexpress
TranscriptomicsC/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence
In blood, the transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver hematopoietic stem cells (HSCs). However, its function in adult HSCs is unknown. Here, using an inducible knockout model, we found that C/EBPa deficien...
ORGANISM(S): Mus musculus 
2012-11-14 | E-GEOD-42234 | biostudies-arrayexpress
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