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UnknownLongitudinal Changes in Cholesterol Efflux Capacities in Patients With Coronary Artery Disease Undergoing Lifestyle Modification Therapy.
Not available
S-EPMC6015361 | biostudies-literature
GenomicsRomidepsin and azacitidine synergize in their epigenetic modulatory effects to induce apoptosis in CTCL
We demonstrate that the combination of the HDAC inhibitor, romidepsin, and the demethylating agent, azacitidine, exerts synergistic anti-proliferative effects and induction of apoptosis involving activation of the caspase cascade in CTCL cell lines as well as CD4+ T cells derived from patients with ...
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-66732 | biostudies-arrayexpress
ProteomicsProteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Background MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but also development of drug resistance within a median progression-free survival (PFS) of 9 to 12 months. Understanding mechanisms of resistance and identifying effective therapeutic al...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082948 | MassIVE
TranscriptomicsscRNAseq of freshly dissociated and cultured skin biopsies
We describe new optimised skin tissue dissociation protocol to digest ex vivo cultured and fresh human skin samples. Using scRNAseq analysis we created skin atlas composition of fresh and cultured skin samples and integrate it with other publicly available skin tissue scRNAdata to compare the qualit...
ORGANISM(S): Homo sapiens 
2022-08-04 | E-MTAB-11509 | biostudies-arrayexpress
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
ProteomicsSPANX immunoprecipitation analysis by mass spectrometry
A375 cells transduced with empty pLVX or pLVX-SPANXA-FLAG were subjected to immunoprecipitation using Flag beads. Elution from beads was performed by incubation with 3XFlag peptide for 1h at 4 C and eluates were subjected to tryptic digestion followed by LC-MS/MS, as described previously (PMID: 3099...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-24 | MSV000084617 | MassIVE
UnknownLKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Not available
S-SCDT-10_15252-EMMM_202317719 | biostudies-other
UnknownGeographics and bacterial networks differently shape the acquired and latent global sewage resistomes.
Not available
S-EPMC12639157 | biostudies-literature
UnknownThrombectomy for Stroke With Large Infarct on Noncontrast CT: The TESLA Randomized Clinical Trial.
Not available
S-EPMC11420819 | biostudies-literature
UnknownNeuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.
Not available
S-EPMC12015082 | biostudies-literature
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