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TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | E-GEOD-35240 | biostudies-arrayexpress
ProteomicsProteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Background MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but also development of drug resistance within a median progression-free survival (PFS) of 9 to 12 months. Understanding mechanisms of resistance and identifying effective therapeutic al...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082948 | MassIVE
ProteomicsSimultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Background MS-based proteotyping has been widely used for biomarker discovery. However, the clinical/translational proteotyping community requires strategies that not only enable the discovery of novel biomarker candidates but also increase the likelihood of establishing these protein-based biomarke...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092996 | MassIVE
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
ProteomicsSPANX immunoprecipitation analysis by mass spectrometry
A375 cells transduced with empty pLVX or pLVX-SPANXA-FLAG were subjected to immunoprecipitation using Flag beads. Elution from beads was performed by incubation with 3XFlag peptide for 1h at 4 C and eluates were subjected to tryptic digestion followed by LC-MS/MS, as described previously (PMID: 3099...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-24 | MSV000084617 | MassIVE
UnknownGlobal incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC11122111 | biostudies-literature
UnknownBurden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC11121021 | biostudies-literature
UnknownGlobal burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC11120204 | biostudies-literature
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