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UnknownPhase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status.
Not available
S-EPMC3804291 | biostudies-literature
TranscriptomicsMouse kidney arteriolar smooth muscle cells derived from the renin cell lineage: control vs. forskolin treatment to induce renin expression
miRNA profiling of mouse kidney arteriolar smooth muscle cells (aSMCs) of the renin lineage comparing control untreated cells with cells treated with forskolin to induce renin expression. Two condition experiment: control untreated aSMCs vs forskolin treated aSMCs; Biological replicates: control 3, ...
ORGANISM(S): Mus musculus 
2012-02-25 | E-GEOD-31780 | biostudies-arrayexpress
TranscriptomicsMouse kidney cortex: control vs. low sodium diet + captopril treatment
miRNA profiling of mouse kidney cortex comparing control vs. low sodium diet + captopril treatment to induce renin expression. Two condition experiment: control vs treated; biological replicates: individual mice - 3 control, 3 treated. One replicate per array.
ORGANISM(S): Mus musculus 
2012-02-25 | E-GEOD-31779 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Plexiform Leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids
Plexiform leiomyomata are a histologically defined subgroup of benign uterine smooth muscle tumors based on their epitheliod cytology and abundant extracellular matrix. We used microarrays to compare plexiform leiomyomata to normal myometrium (smooth muscle of the uterine wall), typical leiomyomata,...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9511 | biostudies-arrayexpress
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension (Illumina)
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-21097 | biostudies-arrayexpress
TranscriptomicsEffect of prolonged stretch on transcript profile of human pregnant myometrium
Context: Increased uterine stretch appears to increase the risk of preterm labour, but the mechanism is unknown. Objectives: To identify a targetable mechanism mediating the effect of stretch on human myometrium. Design: Myometrial explants, prepared from biopsies obtained at elective caesarean de...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-31329 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of two populations of non-hematopoetic stem cells (MSC and MAPC) isolated from human bone marrow.
Compare the behaviour of two populations of non-hematopoetic stem cells (MSC and MAPC) isolated from human bone marrow. The effect of culture conditions on the behaviour of MSC was also characterised by isolating MSC and then culturing the cells for 96h in MAPC growth conditions
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-466 | biostudies-arrayexpress
TranscriptomicsCaMKII inhibition in smooth muscle cells controls Ang-II-induced gene transcription in the aorta
The Ca2+/calmodulin-dependent kinase II is expressed in smooth muscle and believed to mediate intracellular calcium handling and calcium-dependent gene transcription. CaMKII is activated by Angiotensin-II. The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by Angiotensi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-64613 | biostudies-arrayexpress
UnknownInteractions between the lipidome and genetic and environmental factors in autism.
Not available
S-EPMC10115648 | biostudies-literature
TranscriptomicsTranscription profiling of lesional and non-lesional skin from actopic dermititis patients and normal skin
Atopic dermatitis (AD) is a common pruritic dermatitis with macroscopically nonlesional skin that is often abnormal. Therefore, we used high-density oligonucleotide arrays to identify cutaneous gene transcription changes associated with early AD inflammation as potential disease control targets. S...
ORGANISM(S): Homo sapiens 
2006-10-01 | E-GEOD-5667 | biostudies-arrayexpress
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