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TranscriptomicsMicroarray analysis of newborn mice carrying a mutation in miR-96, compared to wildtype sex-matched littermate controls.
The diminuendo mouse carries a mutation in the seed region of miR-96. Adult homozygotes are deaf and display vestibular defects, heterozygotes have rapidly progressive hearing loss. Microarray analysis of four day old homozygotes showed multiple transcripts were misregulated. Because the effect of t...
ORGANISM(S): Mus musculus 
2016-02-26 | E-MTAB-3735 | biostudies-arrayexpress
TranscriptomicsAnalysis of RNA associated with the RISC complex (Ago2) in four day old mice carrying a mutation in miR-96
The diminuendo mouse carries a mutation in the seed region of miR-96. Homozygotes are deaf and exhibit vestibular dysfunction, heterozygotes display rapidly progressive hearing loss. Some targets of miR-96 are known, but it is likely that many still remain to be discovered. MicroRNAs function by rec...
ORGANISM(S): Mus musculus 
2016-02-26 | E-MTAB-3737 | biostudies-arrayexpress
TranscriptomicsComparison of organ of Corti RNA from Ptprq-CAT-KO homozygotes and wildtype littermates
Ptprq is one of the genes markedly downregulated in the diminuendo mouse, which carries a mutation in the microRNA miR-96. We carried out microarrays on mice homozygous for a functional null allele of Ptprq and their wildtype littermates to compare expression changes to those seen in diminuendo homo...
ORGANISM(S): Mus musculus 
2014-01-27 | E-MTAB-1785 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mutant for microRNA-96 vs. wildtype mice to identify potential targets
The Diminuendo mouse mutant strain displays progressive deafness and carries a mutation in the gene mmu-mir-96, a microRNA. We carried out a microarray analysis using RNA extracted from the organ of Corti from 4-day old mutant (n=6) and wildtype (n=6) mice to compare gene expression of both direct a...
ORGANISM(S): Mus musculus 
2009-03-26 | E-TABM-489 | biostudies-arrayexpress
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