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ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
TranscriptomicsThe role of Gaq in MLL leukemogenesis
Beta-catenin has a central role for self-renewal of leukemic stem cells in Mixed Lineage Leukemia (MLL)-arranged acute myeloid leukemia (AML), however its upstream modulators that can enhance this pathway remain largely unexplored. Through genome-wide gene expression analysis, we identified a previo...
ORGANISM(S): Mus musculus 
2016-02-25 | E-MTAB-4078 | biostudies-arrayexpress
ProteomicsUnusual cardiac myosin heavy chain post-translational modifications with systolic heart failure
In the present study, we aimed at defining whether cardiac myosin heavy chain (MYH7) post-translational modifications would be altered in systolic heart failure. For that, we had access to septal tissue from donors and from patients with non-genetic dilated cardiomyopathy or with ischemic cardiomyop...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076695 | Pride
Heart failure  systolic dysfunction  myh7  myosin 
TranscriptomicsTranscription profiling of human T-cell lymphoblastic leukemia, acute mylelogenous leukemia and Diffuse Large Cell Lymphoma cell lines after treatment with aplidin and/or cytarabine
Aplidin (plitidepsin) is a novel antitumor agent isolated from the Mediterranean tunicate Aplidium albicans. Aplidin has shown impressive in vitro and in vivo activity against various cancer cell lines. Based on the results from several laboratories Aplidin has recently been granted orphan drug desi...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-5681 | biostudies-arrayexpress
TranscriptomicsFDB1_GM-CSFTyr577_Receptor_Mutant_Factorial_Time_Course_Study
To understand better the mechanisms controlling the balance between proliferation and and differentiation during myelopoiesis we have utilized teh bi-potent FDB1 myeloid cell line which differentiates to granulocytes and macrophages in response to GM-CSF and thus provides a dissectable model to anal...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-25857 | biostudies-arrayexpress
UnknownMetformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Not available
S-EPMC8189765 | biostudies-literature
UnknownThe Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics.
Not available
S-EPMC5804835 | biostudies-literature
UnknownScalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
Not available
S-EPMC6075717 | biostudies-literature
UnknownMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Not available
S-EPMC3354734 | biostudies-literature
UnknownPathogenic Germline Variants in 10,389 Adult Cancers.
Not available
S-EPMC5949147 | biostudies-literature
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