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TranscriptomicsCOMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS
This SuperSeries is composed of the following subset Series: GSE23672: COMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS (AGILENT ARRAYS) GSE33948: COMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS (AFFYMETRIX ARRAYS...
ORGANISM(S): Mus musculus 
2012-08-12 | E-GEOD-33949 | biostudies-arrayexpress
TranscriptomicsCOMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS (AGILENT ARRAYS)
The identification of Lgr5 as an intestinal stem cell marker has made it possible to isolate and study primary intestinal stem cells. Applying quantitative mass spectrometry as well as transcriptomic analysis, we profiled the protein and gene changes between FACS-sorted Lgr5+ve stem cells and their ...
ORGANISM(S): Mus musculus 
2012-08-12 | E-GEOD-23672 | biostudies-arrayexpress
TranscriptomicsPaneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Homeostasis of self-renewing small intestinal crypts results from neutral competition between Lgr5 stem cells, small cycling cells located at crypt bottoms1, 2. Lgr5 stem cells are interspersed between terminally differentiated Paneth cells, that are known to produce bactericidal products such as ly...
ORGANISM(S): Mus musculus 
2010-11-29 | E-GEOD-25109 | biostudies-arrayexpress
TranscriptomicsCOMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS (AFFYMETRIX ARRAYS)
The identification of Lgr5 as an intestinal stem cell marker has made it possible to isolate and study primary intestinal stem cells. Applying quantitative mass spectrometry as well as transcriptomic analysis, we profiled the protein and gene changes between FACS-sorted Lgr5+ve stem cells and their ...
ORGANISM(S): Mus musculus 
2012-08-12 | E-GEOD-33948 | biostudies-arrayexpress
TranscriptomicsRNA-seq of LGR5(+) and LGR5(-) cells isolated from human colon adenoma organoids and targeted DNA-seq of a colorectal biobank
This study has two components: (1) Human colon adenoma organoids (n=4 patients) were dissociated into single cells. Cells were incubated with a magnetic bead bound to an LGR5 antibody and run through a magnetic column. Magnet bound cells and flow through negative (FTN) cells were obtained. Magnet bo...
ORGANISM(S): Homo sapiens 
2020-04-30 | E-MTAB-4698 | biostudies-arrayexpress
TranscriptomicsLgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin
Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair fol...
ORGANISM(S): Mus musculus 
2010-03-25 | E-GEOD-20269 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Lgr5 positive cells within intestinal adenomas
The generation of the Lgr5_EGFP_ires_CreERT2 knock-in mouse allows marking of Lgr5 positive cells of different tissues. Here we use these mice to sort Lgr5 positive cells and their daughter cells form intestinal adenomas and describe the expression profile of these two cell populations. Intestinal a...
ORGANISM(S): Mus musculus 
2012-08-12 | E-GEOD-37926 | biostudies-arrayexpress
TranscriptomicsGene expression profiling along the intestinal crypt axis.
The identification of Lgr5 as an intestinal stem cell marker has made it possible to isolate and study primary intestinal stem cells. Transcriptional differences between intestinal stem cells can be explored by the use of the Lgr5-eGFP-ires-CreERT2 knock-in mouse. In this mouse model GFP expression ...
ORGANISM(S): Mus musculus 
2012-08-15 | E-GEOD-36497 | biostudies-arrayexpress
TranscriptomicsGene expression signature of fast and slow cycling intestinal crypt base columnar cell populations
The identification of Lgr5 as an intestinal stem cell marker has made it possible to isolate and study primary stem cells from small intestine. Using the cell cycle specific expression og the mKi67 gene, we generated a novel Ki67-RFP knock-in allele which identifies dividing cells. Using Lgr5-GFP;Ki...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-52813 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse intestinal cells expressing Lgr5 at high or low levels or with Ascl2 conditionally knocked out shows Ascl2 controls intestinal stem cell fate
The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy the villi. We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expressio...
ORGANISM(S): Mus musculus 
2009-03-25 | E-GEOD-14201 | biostudies-arrayexpress
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