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ProteomicsQuantitative Proteomic Analysis of an Alexander Disease Murine Model with Severe Reactive Gliosis
We performed label-free micro-data-independent acquisition (µDIA) to assay brain proteins from a severe model of Alexander disease (AxD, lethal at postnatal day ~35). Of the 5,005 proteins quantified, we observed upregulation of adipocytokine signaling, PPAR, insulin resistance, and glutathione pat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-30 | PXD021884 | Pride
Reactive gliosis Alexander disease Parallel reaction monitoring Data-independent acquisition Brain proteome 
UnknownTissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.
Not available
S-EPMC5954157 | biostudies-literature
TranscriptomicsExpression Analysis of Mammary Epithelial Cells Isolated from 12-16 Week Old Virgin C57Bl6 Lrp5+/+ and Lrp5-/- Mice
Investigation of whole-genome gene expression level changes in C57Bl6 Lrp5-/- mammary epithelial cells, compared to the wild-type strain. The mammary epithelial cells were isolated from numbers 4 and 5 mammary glands. The Lrp5-/- mouse strain described in this study has been further described in Lin...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-19228 | biostudies-arrayexpress
MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
UnknownSplice site, frameshift, and chimeric GFAP mutations in Alexander disease.
Not available
S-EPMC3674965 | biostudies-literature
UnknownProtein changes in immunodepleted cerebrospinal fluid from a transgenic mouse model of Alexander disease detected using mass spectrometry.
Not available
S-EPMC3568661 | biostudies-literature
UnknownReduction of π-Expanded Cyclooctatetraene with Lithium: Stabilization of the Tetra-Anion through Internal Li+ Coordination.
Not available
S-EPMC7898929 | biostudies-literature
TranscriptomicsExpression data from hepatitis E virus inoculated PLC/PRF/5 cells
Hepatitis E virus (HEV) is an important causative pathogen of acute hepatitis. Because of the absence of an in vitro culture system for HEV, research has been greatly impeded. And interaction between HEV and host cells was mainly studied by tansfection/transinfection system, such as Adeno virus tran...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-53731 | biostudies-arrayexpress
UnknownUnderstanding the Degradation of a Model Si Anode in a Li-Ion Battery at the Atomic Scale.
Not available
S-EPMC9486947 | biostudies-literature
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
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