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(p)ppGpp is a key player in reprogramming transcriptomes to respond to nutritional challenges. Here, we present a transcriptional and phenotypic differences of A. pleuropneumoniae grown in different chemically defined media in the absence of (p)ppGpp. We show that the deprivation of branch-chain ami...
ORGANISM(S): Actinobacillus pleuropneumoniae 
This platform generates compound libraries in situ, allowing proteins to template the formation of optimal ligands, while ABPP provides a high-throughput, mass spectrometry-based readout for ligand screening. We applied this platform to discover covalent inhibitors for serine hydrolases, including P...
ORGANISM(S): Homo Sapiens 
2025-05-19 | PXD064043 |
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