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UnknownDeciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
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S-EPMC7176980 | biostudies-literature
UnknownAGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial.
Not available
S-EPMC9644559 | biostudies-literature
UnknownMalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites.
Not available
S-EPMC10577899 | biostudies-literature
UnknownEfficacy of different traditional Chinese medicine decoctions in the treatment of ischemic stroke: a network meta-analysis.
Not available
S-EPMC11565597 | biostudies-literature
TranscriptomicsChemical Pull-Down Reveals Comprehensive and Dynamic Pseudouridylation in Mammalian Transcriptome
Pseudouridine (Ψ) is the most abundant RNA modification, yet little is known about its content, dynamics and function in mRNA and ncRNA. Here, we perform quantitative MS analysis and develop CAP-seq for transcriptome-wide Ψ profiling. The unexpected high Ψ content (Ψ/U ratio: ~ 0.2% to 0.6%) indicat...
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-63655 | biostudies-arrayexpress
TranscriptomicsReversible and Dynamic m1A Methylation in the Human Transcriptome
N1-methyladenosine (m1A) is an abundant post-transcriptional RNA modification, yet little is known about its prevalence, topology and dynamics in mRNA. Here, we show that m1A is abundant in human mRNA, with an m1A/A ratio of ~0.02%. We develop m1A-ID-Seq, based on m1A immunoprecipitation and the in...
ORGANISM(S): Homo sapiens 
2016-02-05 | E-GEOD-73941 | biostudies-arrayexpress
ProteomicsAffinity purification of TRMT6/61A protein complexes
In order to identify the molecular mechanism leading to the increase of TRMT6/61A complex in aged HSCs, we purified proteins interacting with TRMT6 and TRMT61A via affinity purification. HEK293T cells stably expressing SFB-tagged TRMT6 or SFB-TRMT61A were lysed in NETN buffer (20 mM Tris-HCl [pH 8.0...
ORGANISM(S): Homo Sapiens 
2023-11-30 | PXD047430 |
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters (ChIP-chip)
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with tiling array ChIP-chip and RNA-seq to characterize the early dynamics of expression of coding and non-coding RNAs and epigenetics in and around the Hox clusters. Expre...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-61584 | biostudies-arrayexpress
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters (tiling)
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with expression tiling arrays to characterize the early dynamics of expression of coding and non-coding RNAs in and around the Hox clusters. Gene expression is examined at ...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-61585 | biostudies-arrayexpress
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters.
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with expression tiling arrays and RNA-seq to characterize the early dynamics of expression of coding and non-coding RNAs in and around the Hox clusters. Gene expression is ...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-67610 | biostudies-arrayexpress
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