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TranscriptomicsArf Tumor Suppressor and miR-205 Regulate Cell Adhesion and Formation of Extraembryonic Endoderm from Pluripotent Stem Cells
Induction of the Arf tumor suppressor in response to hyperproliferative stress following oncogene activation activates a p53-dependent transcriptional program that limits the expansion of incipient cancer cells. Although Arf is not expressed in most tissues of fetal or young adult mice, it is physi...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-42210 | biostudies-arrayexpress
GenomicsPHB Acts as a Member of the HIRA Complex to Control an Epigenetic and Metabolic Circuitry
Cellular metabolism and chromatin landscape both contribute to cell fate determination. However, their interplay remains poorly understood. Here we show that Prohibitin (PHB), an evolutionarily conserved protein, involves in a histone variant H3.3 chaperon HIRA complex-dependent epigenetic and metab...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-72143 | biostudies-arrayexpress
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