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MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
MetabolomicsMetabolomics analysis of the toxic effects of the production of lycopene and its precursors
Using cells as microbial factories enables highly specific production of chemicals with many advantages over chemical syntheses. A number of exciting new applications of this approach are in the area of precision metabolic engineering, which focuses on improving the specificity of target production....
2021-02-11 | MTBLS642 | MetaboLights
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090883 | MassIVE
TranscriptomicsRNA sequencing of sperm extracted from the epididymis in naked mole-rat subordinates, naked mole-rat ex-subordinates, and mice
Naked mole-rat show a strong phenotype of sperm hypo-motility and abnormal morphology. Comparative genomic analyses in our study presenting the telomere-to-telomere genome for the naked mole-rat identified several sperm-gene relaxation and sperm-gene loss events in the NMR. To test the transcriptomi...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-17270 | biostudies-arrayexpress
TranscriptomicsPet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability.
Newborn neurons enter an extended maturation stage, during which they acquire excitability characteristics crucial for development of presynaptic and postsynaptic connectivity. In contrast to earlier specification programs, little is known aboutthe regulatory mechanisms that control neuronal maturat...
ORGANISM(S): Mus musculus 
2016-01-08 | E-GEOD-74315 | biostudies-arrayexpress
TranscriptomicsEpigenetic and genetic influences on DNA methylation variation in maize populations
DNA methylation is a chromatin modification that is frequently associated with epigenetic regulation in plants and mammals. However, other genetic changes such as transposon insertions also can lead to changes in DNA methylation levels. Genome-wide profiles of DNA methylation levels for 20 maize i...
ORGANISM(S): Zea mays 
2013-08-12 | E-GEOD-46949 | biostudies-arrayexpress
UnknownA somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.
Not available
S-EPMC5988034 | biostudies-literature
UnknownA Zeb1/MtCK1 Metabolic Axis Controls Osteoclast Activation and Skeletal Remodeling
Not available
S-SCDT-10_15252-EMBJ_2022111148 | biostudies-other
GenomicSporadic Autism Exomes Reveal a Highly Interconnected Protein Network of De Novo Mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component; however, for at least 70% of cases, the underlying genetic cause is unknown. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no ...

phs000482 | dbGaP
UnknownCNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.
Not available
S-EPMC11833661 | biostudies-literature
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