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ProteomicsCovalent Organic Framework with Acid Precipitation Enhances Microprotein Enrichment and Discovery of Ferroptosis-Associated Microproteins
Microproteins, defined as polypeptides fewer than 100 amino acids, are encoded by small open reading frames (sORFs) and exhibit unique structural and functional characteristics. Despite their short length and recent discoveries, microproteins have already been found to play critical roles in diverse...
ORGANISM(S): Homo Sapiens 
2026-02-26 | PXD074935 |
ProteomicsImproved in situ Characterization of Proteome-wide Protein Complex Dynamics with Thermal Proximity Co-Aggregation
Vast majority of cellular activities are carried out by protein complexes that assembled dynamically in response to cellular needs and environmental cues. Disarrayed cellular activities could arise from dysregulated protein complexes leading to diseases and developmental defects. Large scale efforts...
ORGANISM(S): Homo Sapiens 
2023-02-13 | PXD040078 |
ProteomicsInvestigating the off-target effects of Pro-BA using label-free and TMTpro quantitative proteomics
Nevertheless, in-depth characterization of the proteome could reveal unknown off-targets of Pro-BA. To address this issue, we repeated the same experiment but extended MS analysis time to 2 hours in this revision, which will be elaborated in the next point. Nonetheless, the computed p-value of ALK p...
ORGANISM(S): Homo Sapiens 
2025-03-25 | PXD062245 |
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