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GenomicsThe Cytokines IL-21 and GM-CSF have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells
Interleukin-21 (IL-21) has broad actions on T- and B-cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis of conventional dendritic cells (cDCs) via STAT3 and Bim, and this was inhibited by granulocyte-macrophage colony-stimulating factor (GM-CSF...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-27161 | biostudies-arrayexpress
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
UnknownCharacterization of Chromium Waste Form Based on Biocementation by Microbacterium sp. GM-1.
Not available
S-EPMC4920760 | biostudies-literature
MetabolomicsTranscriptome and metabolome changes in Chinese cedar during cold acclimation reveal the roles of flavonoids in needle discoloration and cold resistance

Cryptomeria fortunei growth and development are usually affected by low temperatures. Despite the evergreen nature of this species, most needles turn yellowish-brown in cold winters. The underlying discoloration mechanisms that cause this phenomenon in response to cold acclimation remain...

2022-08-12 | MTBLS3184 | MetaboLights
UnknownGM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages.
Not available
S-EPMC8721478 | biostudies-literature
TranscriptomicsDiscovery of the genes controlled by the second messenger cyclic di-GMP in Mycobacterium tuberculosis
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many biological processes in bacteria. The genome in Mycobacterium tuberculosis encodes a single copy of the diguanylate cyclase gene (dgc) responsible for c-di-GMP synthesis. To determine the role of c-di-GMP signaling in M. t...
ORGANISM(S): Mycobacterium tuberculosis 
2013-10-09 | E-GEOD-37973 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human vitamin C-induced gene expression in GM5659 skin fibroblasts
The skin is a protective barrier against external insults and any lesion must be rapidly and efficiently repaired. Dermal fibroblasts are the major source of extracellular connective tissue matrix and play an important role in wound healing. Vitamin C is an important water-soluble free radical scave...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-11919 | biostudies-arrayexpress
TranscriptomicsPorcine spleen_Haemophilus Parasuis infected_7days
Haemophilus parasuis(HPS) is a prominent swine pathogen that causes GlM-CM-$sser's disease characterized by fibrinous polyserositis, meningitis and arthritis; however, the molecular mechanisms underlying disease pathogenesis remains poorly understood, particularly the host counteraction to HPS invas...
ORGANISM(S): Sus scrofa 
2009-03-26 | E-GEOD-11787 | biostudies-arrayexpress
TranscriptomicsRNA Sequencing Analysis of Mouse Bone Marrow Derived Dendritic Cells Transcriptomes During Maturation
Purpose:The purpose of this study is to detect activated or silenced genes during LPS-induced dendritic cell maturation. Gene expression differences between two samples could be found using transcriptome profiling (RNA-seq) analysis. Methods:Mouse dendritic cells were generated from bone marrow cell...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-60307 | biostudies-arrayexpress
UnknownGM-Improved Antiaging Effect of Acrylonitrile Butadiene Styrene in Different Thermal Environments.
Not available
S-EPMC7023587 | biostudies-literature
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