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TranscriptomicsTime-course gene expression profiles of a Saccharomyces cerevisiae wild type and long-lived sch9-delta mutant
The SCH9 null strain has smaller cell size, grows at a slower rate and survives three times longer than wide-type yeast. This study aims to dissect the mechanisms that lead to the yeast life span extension of sch9-delta. We measure gene expression profiles of the S. cerevisiae wild type and the lon...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-24 | E-GEOD-14227 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Streptomyces avermitilis NRRL8165 delta-aveI mutant
Investigation of whole genome gene expression level changes in Streptomyces avermitilis delta-aveI mutant, compared to the wild-type strain. The mutants analyzed in this study are further described in Chen L, Lu Y., Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W. (2008) Characterization of a negativ...
ORGANISM(S): Streptomyces avermitilis 
2010-05-16 | E-GEOD-16892 | biostudies-arrayexpress
UnknownA Novel Splice-Site Mutation in MSH2 Is Associated With the Development of Lynch Syndrome.
Not available
S-EPMC7318799 | biostudies-literature
GenomicsRegulation of Mammalian Cell Growth and Survival By an RNA Polymerase II-Pausing Factor (ChIP-seq)
Many mammalian genes are occupied by paused RNA polymerase II (pol II) at promoter-proximal regions on both sides of transcription start sites (TSSs). However, the consequences of pol II pausing on gene expression and cell biology are not fully understood. Here we report that genetic ablation of t...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-24113 | biostudies-arrayexpress
TranscriptomicsGenes differentially expressed in Haloferax mediterranei strains, DF50 and M-NM-^TdeoR2, with or without induction by fructose
Transcriptional profiling of Haloferax mediterranei DF50 and M-NM-^TdeoR2 with induction by fructose comparing with the strains without this induction. Goal was to explore the effect of induction by fructose on Haloferax mediterranei. Total RNA from the Haloferax mediterranei DF50 and M-NM-^TdeoR2 w...
ORGANISM(S): Haloferax mediterranei 
2013-12-18 | E-GEOD-41134 | biostudies-arrayexpress
UnknownHSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials.
Not available
S-EPMC12103582 | biostudies-literature
UnknownThe transition from hypertension to hypertensive heart disease and heart failure with preserved ejection fraction: a retrospective cross-sectional study of myocardial magnetic resonance strain and tissue characteristics.
Not available
S-EPMC11485389 | biostudies-literature
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsDNA polymerase iota alleviates replication stress-induced genome instability during mitosis
DNA polymerase iota (Pol ι) is a Y-family lesion bypass polymerases, characterized by its remarkably low fidelity. While Pol ι is ubiquitously expressed in nearly all cell types, its function remains largely undefined. Previous studies in cellular and mouse models deficient in Pol ι have revealed no...
ORGANISM(S): Human Parechovirus Strain T82-0169 
2025-07-01 | PXD065672 |
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