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TranscriptomicsCardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo
Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypica...
ORGANISM(S): Mus musculus 
2009-06-03 | E-GEOD-11661 | biostudies-arrayexpress
TranscriptomicsMuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.
MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy Four strain-matched groups of 3-8 week old mice were investigated: 1) MuRF1 -/- Fenofibrate feed; 2) MuRF1 -/- chow feed; 3) MuRF1 +/+ Fenofibrate feed; 4) MuRF1 +/+ chow feed at...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-68480 | biostudies-arrayexpress
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