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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
UnknownSelectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacy.
Not available
S-EPMC12319579 | biostudies-literature
UnknownInduction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.
Not available
S-EPMC4898475 | biostudies-literature
UnknownThe evolutionary dynamics and epidemiological history of hepatitis C virus genotype 6, including unique strains from the Li community of Hainan Island, China.
Not available
S-EPMC9115904 | biostudies-literature
UnknownProduction of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction.
Not available
S-EPMC7094453 | biostudies-literature
UnknownK2CO3-Promoted oxy-Michael Addition/Cyclization of α,β-Unsaturated Carbonyl Compounds with Naphthols: Synthesis of Naphthopyrans.
Not available
S-EPMC10385152 | biostudies-literature
ProteomicsG4-RNA binding proteins from K562
G-quadruplex RNA pulldown followed by mass spectrometry. G4A4 oligoribonucleotide (5’-AAAAAAGGGGAAAAGGGGAAAAGGGGAAAAGGGGAAAAAA-3’) was biotinylated and folded in either K+ or Li+ containing buffers, causing folding of G-quadruplex (K+) or destabilization of the secondary structure (Li+). G4A4 pulldo...
ORGANISM(S): Homo sapiens (Human) 
2024-02-20 | PXD041154 | Pride
Rna pulldown G-quadruplex rna 
UnknownMechanistic Insight Into the AuCN Catalyzed Annulation Reaction of Salicylaldehyde and Aryl Acetylene: Cyanide Ion Promoted Umpolung Hydroacylation/Intramolecular Oxa-Michael Addition Mechanism.
Not available
S-EPMC6691126 | biostudies-literature
TranscriptomicsTranscription profiling of synectin knock-out mouse primary endothelial cells before and after FGF2 induction
Transcriptional regulatory effects of synectin deletion in murine primary endothelial cells both before and after FGF2 induction.
ORGANISM(S): Mus musculus 
2006-10-01 | E-MEXP-820 | biostudies-arrayexpress
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