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TranscriptomicsDifferential Expressions of miRNAs in resting and activated human in vitro-differentiated NK cells
To investigate miRNA expressions of miRNA upon activation. In vitro-differentiated human NK cells were freshly incubated in the presence of IL15 after 24h deprivation of IL-15. The cells were harvested at the times (0h, resting-Sample 1 and 2; 6h, activated-Sample 3 and 4) and analyzed by microarray...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-32411 | biostudies-arrayexpress
UnknownNoninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes.
Natural killer (NK) cells are key innate immunity effectors that combat viral infections and control several cancer types. For their immune function, human NK cells rely largely on five different cytotoxic proteases, called granzymes (A/B/H/K/M). Granzyme B (GrB) initiates at least three distinct ce...
S-EPMC7363135 | biostudies-literature
UnknownSafety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial.
There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells expressing anti-CD19 chimeric antigen receptor and interleukin-15 (CAR19/IL-15) in 37 ...
S-EPMC10957466 | biostudies-literature
UnknownIFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella.
Metastasis accounts for 90% of cancer-related deaths and, currently, there are no effective clinical therapies to block the metastatic cascade. A need to develop novel therapies specifically targeting fundamental metastasis processes remains urgent. Here, we demonstrate that Salmonella YB1, an engin...
S-EPMC8099885 | biostudies-literature
UnknownInterleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD.
Glioblastoma (GBM) is an aggressive brain cancer with limited therapeutic options. Natural killer (NK) cells are innate immune cells with strong anti-tumor activity and may offer a promising treatment strategy for GBM. We compared the anti-GBM activity of NK cells engineered to express interleukin (...
S-EPMC11370652 | biostudies-literature
UnknownOvercoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells.
CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226 in NK cell surveillance of acute myeloid leukemia (AML...
S-EPMC11838179 | biostudies-literature
UnknownKIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape.
Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted transfer of the CAR cognate antigen from tumor to ...
S-EPMC9942695 | biostudies-literature
UnknownGenome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency.
Adoptive cell therapy using engineered natural killer (NK) cells is a promising approach for cancer treatment, with targeted gene editing offering the potential to further enhance their therapeutic efficacy. However, the spectrum of actionable genetic targets to overcome tumor and microenvironment-m...
S-EPMC12396527 | biostudies-literature
UnknownCD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis.
Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR-engineered natural killer (NK) cells remains l...
S-EPMC11452288 | biostudies-literature
UnknownBATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML.
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients with myeloid malignancies display global dysfunction...
S-EPMC11967735 | biostudies-literature
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