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ProteomicsDiscovery of novel CRBN ligands by virtual screening and biological evaluation against multiple hematological cancer cell lines
Immunomodulatory drugs, functioning as cereblon (CRBN) E3 ligase ligands, have been approved for treating various hematological malignancies by hijacking the function of CRBN E3 ligase and inducing the degradation of multiple CRBN-associated substrates. However, the inevitable emergence of drug resi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD061290 | Pride
Hematological cancer  imids  crbn ligands  molecular docking  antitumor evaluation 
ProteomicsCrf1-FLAG Mass spectrometry-based proteomics data
Mass spectrometry detection of samples co-precipitated with Crf1-FLAG
ORGANISM(S): Pyricularia Oryzae 70-15 
2025-01-19 | PXD059953 |
ProteomicsProteomics and metabolomics reveal the energy metabolism as a vital response to acupuncture treatment of migraine and the mechanism of disease
Proteomic and metabolomic characterization of migraine patient plasma with acupuncture intervention
ORGANISM(S): Homo Sapiens 
2022-09-21 | PXD028441 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
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