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TranscriptomicsBlood gene expression of rats exposed to acetaminophen or methyl parathion
The purpose of this study was to investigate whether expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ-specific chemical toxicity in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hep...
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-13442 | biostudies-arrayexpress
TranscriptomicsMolecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) a...
ORGANISM(S): Rattus norvegicus 
2012-06-29 | E-GEOD-32147 | biostudies-arrayexpress
TranscriptomicsTranscriptomics Analysis of Lungs and Peripheral Blood of Crystalline Silica Exposed Rats
Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach...
ORGANISM(S): Rattus norvegicus 
2012-12-31 | E-GEOD-36208 | biostudies-arrayexpress
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