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TranscriptomicsTranscription profiling of human CD4+ memory T cells reveals they are preferential targets for bystander activation and apoptosis
There is much evidence that T cells may be activated via mechanisms which act independently of direct TCR ligation. Despite this, the question of whether such forms of ‘bystander’ T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up ...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-13738 | biostudies-arrayexpress
ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
UnknownMir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.
Not available
S-EPMC4402854 | biostudies-literature
MetabolomicsStudy on the Hepatoprotection of Schisandra chinensis Caulis Ploysaccharides in nonalcoholic fatty liver disease in rats based on metabolomics

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCP) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divided into control group (CON), model group...

2021-08-24 | MTBLS3194 | MetaboLights
UnknownmiR-34b/c rs4938723 T>C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children.
Not available
S-EPMC6754906 | biostudies-literature
TranscriptomicsConserved non-coding sequence 2 (CNS2) of the Foxp3 genomic locus is essential for the function and stability of regulatory T cells during their activation
Regulatory T (Treg) cells play an indispensable role in immune homeostasis. The development and function of Tregs are dependent on transcriptional factor Foxp3, but how constant expression of Foxp3 is maintained in Tregs is not clear. Here we show that ablation of the conserved non-coding DNA seque...
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-57272 | biostudies-arrayexpress
UnknownHarnessing A3G for efficient and selective C-to-T conversion at C-rich sequences.
Not available
S-EPMC7893952 | biostudies-literature
TranscriptomicsGenomic expression profiling of TNFalpha treated BDC2.5 diabetogenic CD4+ T Cells
Tumor necrosis factor alpha (TNFalpha) plays an important role in immune regulation, inflammation, and autoimmunity. Chronic TNFalpha exposure has been shown to down-modulate T cell responses. In a mouse T cell hybridoma model, TNFalpha attenuated T cell receptor (TCR) signaling. We have confirme...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-10029 | biostudies-arrayexpress
UnknownCharacterization of a novel chitinolytic Serratia marcescens strain TC-1 with broad insecticidal spectrum.
Not available
S-EPMC9339060 | biostudies-literature
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