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ProteomicsProteome-Wide Deconvolution of Drug Targets and Binding Sites by Lysine Reactivity Profiling
Recently, numerous efforts have been devoted to identifying drug targets and binding sites in complex proteomes, which is of great importance in modern drug discovery. In this study, we developed a robust lysine reactivity profiling method to systematically study drug-binding targets and binding sit...
ORGANISM(S): Homo Sapiens 
2023-09-28 | PXD045749 |
ProteomicsSelective enrichment of N-terminal proline peptides via hydrazide chemistry for proteomics analysis
A challenge for shotgun proteomics is the identification of low abundance proteins, which is always hampered owing to the extreme complexity of protein digests and highly dynamic concentration range of proteins. To reduce the complexity of the peptide mixture, we developed a novel method to selectiv...
ORGANISM(S): Homo Sapiens 
2021-10-18 | PXD029178 |
ProteomicsBaSCX method for enriching methylated peptieds
Protein methylation as one of the most important post-translational modifications of proteins has been under the spotlight due to its essential role in many important biological processes. To data, antibody-based enrichment strategy is the most used approach to enrich methylated peptides. Unfortunat...
ORGANISM(S): Homo Sapiens 
2021-10-18 | PXD029179 |
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