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ProteomicsFinding missing proteins from the epigenetically manipulated human cell with stringent quality criteria
There are three major epigenetic mechanisms, DNA methylation, histone modifications, and ncRNAs. The histone is a key player in epigenetics, and the acetylation and methylation are their most common post-translational modifications (PTMs). These histone modifications have important roles in transcri...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD002453 | Pride
Histone Chromosome-centric human proteome project Epigenetic Missing proteins 
ProteomicsA Hidden Human Proteome Encoded by the “Non-Coding” Genes
It has been a long debate whether the 98% “non-coding” fraction of human genome can encode functional proteins besides a “random noise” of translation. We used our established translatome sequencing (RNC-seq) to analyze human cells and found that up to 3330 long non-coding RNAs (lncRNAs) were bound ...
ORGANISM(S): Homo Sapiens 
2019-08-29 | PXD044056 |
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