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GenomicsTo examine the role of p300 in the SMARCA4–p53 regulatory axis, we performed ChIP-seq to assess p300, p53, H3K27ac, HDAC1, HDAC2 occupancy in BIN-67 cells
ChIP-seq was performed in BIN-67, BIN-67 p53ko, BIN-67 with SMARCA4 restoration and BIN-67 p53ko cells with SMARCA4 restoration to assess the impact of SMARCA4 and p53 on the pull downs of p300, H3K27ac, p53, HDAC1 and HDAC2.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15700 | biostudies-arrayexpress
GenomicsAssessing SMARCA4 restoration contribution to global changes in p300 occupancy in BIN-67 cells
We aim to test how SMARCA4 restoration impacts p300 occupancy distribution. To this aim we generated ChIP-seq samples in BIN-67 with or without A-485 treatment (1 μM, 24h), as a proxy for p300 acetylatransferase inhibition, and BIN-67 with inducible SMARCA4 restoration (1 μg/ml Doxycycline for 24h)....
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15699 | biostudies-arrayexpress
TranscriptomicsMenin-regulated genes in bone marrow B-cell progenitors
MLL1 translocations encode fusion proteins retaining the N-terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis, thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining hematopoietic stem cells (HSCs...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-49120 | biostudies-arrayexpress
GenomicsOpen Chromatin by FAIRE from ENCODE/OpenChrom(UNC Chapel Hill)
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Terry Furey mailto:tsfurey@duke.edu). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). These tracks displa...
ORGANISM(S): Homo sapiens 
2012-01-24 | E-GEOD-35239 | biostudies-arrayexpress
Transcriptomicsp53-ko rescues gene expression changes mediated by p300 acetyltransferase inhibition
RNA-seq samples in BIN-67 and BIN-67p53-ko cells with or without A-485 treatment (1μM, 24h). The goal of the experiment is to assess the genes that are regulated by p300 acetyltransferase inhibition using A-485 treatment and weather p53-ko can rescue this phenotype.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15706 | biostudies-arrayexpress
GenomicsOpen Chromatin by DNaseI HS from ENCODE/OpenChrom(Duke University)
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Terry Furey mailto:tsfurey@duke.edu). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). These tracks displa...
ORGANISM(S): Homo sapiens 
2011-10-14 | E-GEOD-32970 | biostudies-arrayexpress
TranscriptomicsExamining the effect of SMARCA4–p53 regulatory axis on SCCOHT cells transcription
To examine the role SMARCA4-p53 regulatory axis in SCCOHT cells we performed RNA-seq in BIN-67 cells with SMARCA4 restoration, p53ko alone or combined with SMARCA4 and idasanutlin treatment (0.5μM, 24h) which increase the stability of p53 and its protein levels in SCCOHT.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15707 | biostudies-arrayexpress
GenomicsHistone Modifications by ChIP-seq from ENCODE/Broad Institute
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (mailto:nshoresh@broad.mit.edu). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This track displays maps ...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-29611 | biostudies-arrayexpress
TranscriptomicsRNA Subcellular Localization by Paired End diTag Sequencing from ENCODE/GIS
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Yijun Ruan mailto:ruanyj@gis.a-star.edu.sg). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This track i...
ORGANISM(S): Homo sapiens 
2011-11-10 | E-GEOD-33600 | biostudies-arrayexpress
UnknownA Prospective Multicenter Study of the Chinese Scoring System for Hepatitis B Liver Failure.
Not available
S-EPMC8592973 | biostudies-literature
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