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TranscriptomicsMicroarray for LPS-stimulated B cells compared to unstimulated B cells
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. To explore the novel therapeutic target to plasma cells, we determined the gene expression profile in plasma cells by affymetrix microarrays. LPS could effectively in vitro i...
ORGANISM(S): Mus musculus 
2019-08-01 | E-MTAB-7109 | biostudies-arrayexpress
TranscriptomicsMicroarray for B cells of TACI-IgG-treated MRL/lpr mice compared to control mice
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of B cells differentiate into plasmablast/plasma cell is disordered. Despite the continuous research on the development of prognostic factors an...
ORGANISM(S): Mus musculus 
2019-07-30 | E-MTAB-7106 | biostudies-arrayexpress
TranscriptomicsMicroarray for activated B cells compared to naive B cells
B cells encounter antigen to activate and then differentiate into plasma cells. Both multiple myeloma (MM) and some autoimmune diseases such as multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of ...
ORGANISM(S): Mus musculus 
2019-08-01 | E-MTAB-7110 | biostudies-arrayexpress
TranscriptomicsCoordinate Regulation of Metabolites Glycosylation and Stress Hormones Biosynthesis by TT8 in Arabidopsis
Secondary metabolites play a key role in coordinating ecology and defense strategies of plants. Diversity of these metabolites arise by conjugation of core structures with diverse chemical moieties, such as sugars in glycosylation. Active pools of phytohormones, including those involved in plant str...
ORGANISM(S): Arabidopsis thaliana 
2016-07-20 | E-GEOD-59048 | biostudies-arrayexpress
UnknownCyrtomiumadenotrichum (Dryopteridaceae), a new species from Guangxi, China.
Not available
S-EPMC11220402 | biostudies-literature
TranscriptomicsRNA-seq of mouse myeloma cell line SP 2/0 cells compared to naive B cells
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of B cells differentiate into plasmablast/plasma cell is disordered. Despite the continuous research on the development of prognostic factors an...
ORGANISM(S): Mus musculus 
2019-07-31 | E-MTAB-7112 | biostudies-arrayexpress
UnknownDiscovery of a potent, covalent BTK inhibitor for B-cell lymphoma.
Not available
S-EPMC4027949 | biostudies-literature
TranscriptomicsTargeting the MTOR-AKT pathway in DLBCL
The mTOR (mammalian Target of Rapamycin) pathway is constitutively activated in Diffuse Large B-Cell Lymphoma (DLBCL). mTOR inhibition has been shown to have clinical activity in patients with DLBCL, although overall response rates remain low. We therefore evaluated differences in the transcriptome...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-27255 | biostudies-arrayexpress
TranscriptomicsTranslation initiation at a non-AUG start codon for mouse and human NELF-B
Negative elongation factor (NELF), a four-subunit protein complex in metazoan, plays an important role in regulating promoter-proximal pausing of RNA polymerase II (RNAPII). Genetic studies demonstrate that the B subunit of mouse NELF (NELF-B) is critical for embryonic development and homeostasis i...
ORGANISM(S): Mus musculus 
2014-10-11 | E-GEOD-62248 | biostudies-arrayexpress
UnknownA Prospective Multicenter Study of the Chinese Scoring System for Hepatitis B Liver Failure.
Not available
S-EPMC8592973 | biostudies-literature
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