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TranscriptomicsLoss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance
The dismal lethality of lung cancer is due to late stage at diagnosis and inherent therapeutic resistance. The incorporation of targeted therapies has modestly improved clinical outcomes, but the identification of new targets could further improve clinical outcomes by guiding stratification of poor-...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-28282 | biostudies-arrayexpress
ProteomicsQuantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and a lack of effective treatments. The role of abnormal glycosylation in the onset of autoimmune diseases has been recognized for some time. Nonetheless, the intricate details of ...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057509 |
ProteomicsAdipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis
Adipose Energy Homeostasis is the important guarantee to maintain the body's energy balance. Recently, it is reported that, in the adipose cell, Kisspeptins play important role in cell proliferation, differentiation, lipid metabolism and some adipocytokine secretion, so Kisspeptins maybe the novel t...
ORGANISM(S): Mus Musculus 
PXD051630 |
ProteomicsPD-L1 Mediated Immune Evasion in Triple Negative Breast Cancer Is Linked to the Loss of ZNF652
The intrinsic regulation of PD-L1 expression remains unclear. Here we report that ZNF652 is a potent transcription repressor of PD-L1. ZNF652 frequently loses heterozygosity (LOH) in various cancers. Higher LOH rate and lack of estrogen-inducible transcription lead to suppressed expression of ZNF652...
ORGANISM(S): Homo Sapiens 
PXD045945 |
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