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TranscriptomicsAcceSssIble: an array-based assay for the study of chromatin accessibility and DNA methylation using the CpG methyltransferase SssI
Analysis of nucleosome positioning and chromatin state by using CpG methyltransferase M.SssI to methylate nuclei. Unmethylated regions that gain methylation (low to high beta value) are known to be accessible and nucleosome depleted. Intact nuclei are harvested from cells and treated with M.SssI. DN...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-36580 | biostudies-arrayexpress
TranscriptomicsFunctional DNA methylation is accompanied by chromatin accessibility [gene expression]
Analysis of nucleosome positioning and chromatin state by using CpG methyltransferase M.SssI to methylate nuclei. Unmethylated regions that gain methylation (low to high beta value) are known to be accessible and nucleosome depleted. Method used to study changes after epigenetic drug treatments iden...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-43852 | biostudies-arrayexpress
TranscriptomicsFunctional DNA methylation is accompanied by chromatin accessibility [methylation]
Analysis of nucleosome positioning and chromatin state by using CpG methyltransferase M.SssI to methylate nuclei. Unmethylated regions that gain methylation (low to high beta value) are known to be accessible and nucleosome depleted. Method used to study changes after epigenetic drug treatments iden...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-43851 | biostudies-arrayexpress
GenomicsA novel bivalent chromatin state exists at enhancers
We assess global chromatin accessibility following 5-Aza-CdR treatment of HCT116 cells Simultaneous genome-wide mapping of DNA methylation and nucleosome occupancy of HCT116 cells
ORGANISM(S): Homo sapiens 
2016-06-02 | E-GEOD-68046 | biostudies-arrayexpress
GenomicsIdentification of DNA methylation-independent epigenetic events underlying clear cell renal cell carcinoma
Alterations in chromatin accessibility independent of DNA methylation can affect cancer-related gene expression, but are often overlooked in conventional epigenomic profiling approaches. In this study, we describe a cost-effective and computationally simple assay called AcceSssIble to simultaneously...
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-75597 | biostudies-arrayexpress
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