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ProteomicsMacrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates worldwide. Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is involved in neurogenesis and human cancers. However, the role of DCLK1 in atherosclerosis remains undefined. In this st...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD039083 | Pride
Lc-ms/ms 
ProteomicsCardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remo...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD074496 | Pride
Angiotensin ii  cdk9  nf-κb p65  cardiac remodeling  cardiomyocytes 
ProteomicsCardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remo...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-15 | PXD074483 | Pride
Angiotensin ii  cdk9  nf-κb p65  cardiac remodeling  cardiomyocytes 
ProteomicsOTUD7B promotes cardiac hypertrophy by deubiquitinating SERCA2a
Cell samples were lysed in lysis buffer (8 M urea, 1% protease inhibitor cocktail). The supernatant was collected and the protein concentration was determined with BCA kit according to the manufacturer’s instructions. The peptides were obtained by digesting the protein with trypsin. Then, peptides w...
ORGANISM(S): Rattus Norvegicus 
PXD068918 |
UnknownPhylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds: High Homology of Internal Genes with Human H10N8 Virus.
Not available
S-EPMC4770023 | biostudies-literature
TranscriptomicsINO80 complex in the core regulatory network governing ESC self-renewal [728_subunits]
Embryonic stem cell (ESC) self-renewal and pluripotency is controlled by the coordinated action of transcription factors and chromatin regulators. Compared to the pluripotency transcription factors, the function of the chromatin regulators, especially the ATP-dependent chromatin remodelers, remains ...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-49251 | biostudies-arrayexpress
TranscriptomicsINO80 complex in the core regulatory network governing ESC self-renewal [771_timecourse]
Embryonic stem cell (ESC) self-renewal and pluripotency is controlled by the coordinated action of transcription factors and chromatin regulators. Compared to the pluripotency transcription factors, the function of the chromatin regulators, especially the ATP-dependent chromatin remodelers, remains ...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-49250 | biostudies-arrayexpress
TranscriptomicsBbssk1 dependent gene expression in Beauveria bassiana
Ssk1-type response regulator proteins are the core elements of histidine-to-aspartate systems that mediate fungal stress tolerance, a determinant to the biocontrol potential of fungal entomopathogens. We characterized for the first time the functions of Beauveria bassiana Ssk1 (Bbssk1) by analyzing ...
ORGANISM(S): Beauveria bassiana ARSEF 2860 
2012-08-21 | E-GEOD-40229 | biostudies-arrayexpress
TranscriptomicsAll Differentially Expressed miRNA in burned murine skin tissue compared to normal skin tissue
Interactions between stromal cell-derived factor-1M-NM-1 (SDF-1M-NM-1) and its cognate receptor CXCR4 are crucial for the recruitment of mesenchymal stem cells (MSCs) from bone marrow (BM) reservoirs to damaged tissues for repair during alarm situations. MicroRNAs are differentially expressed in ste...
ORGANISM(S): Mus musculus 
2013-05-07 | E-GEOD-46660 | biostudies-arrayexpress
UnknownTMED2 promotes epithelial ovarian cancer growth.
Not available
S-EPMC5706863 | biostudies-literature
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