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TranscriptomicsA Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA [SHSY5Y cells]
Long non-coding RNAs (lncRNAs) are a diverse category of transcripts with poor conservation and have expanded greatly in primates, particularly in their brain. We identified a lncRNA, which has acquired 16 microRNA response elements (MREs) for miR-143-3p in the Catarrhini branch of primates. This ln...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-73982 | biostudies-arrayexpress
TranscriptomicsA Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA [single cell sequencing analysis]
Long non-coding RNAs (lncRNAs) are a diverse category of transcripts with poor conservation and have expanded greatly in primates, particularly in their brain. We identified a lncRNA, which has acquired 16 microRNA response elements (MREs) for miR-143-3p in the Catarrhini branch of primates. This ln...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-74207 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq with Waterfall Reveals Molecular Cascades underlying Adult Hippocampal Neurogenesis
Somatic stem cells contribute to tissue ontogenesis, homeostasis, and regeneration through sequential processes. Systematic molecular analysis of stem cell behavior is challenging because classic approaches cannot resolve cellular heterogeneity or capture developmental dynamics. Here we provide a co...
ORGANISM(S): Mus musculus 
2015-08-30 | E-GEOD-71485 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis H37Rv and the isogenic mprA::Kmr mutant
Whole genome expression analyses between wild-type Mycobacterium tuberculosis H37Rv and the isogenic mprA::Kmr mutant. Expression analyses between these strains were conducted following growth under physiological conditions, or following exposure to non-inhibitory concentrations of SDS or Triton X-...
ORGANISM(S): Mycobacterium tuberculosis 
2006-03-01 | E-MEXP-552 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the demosponge Amphimedon queenslandica at life cycle transitions
Poriferans, like the demosponge Amphimedon queenslandica, are the earliest diverging metazoans and may hold the key to understanding the evolution of metazoan pathways. A. queenslandica exhibits a biphasic lifecycle, with free-swimming larvae and sessile adult stages. To study changes in the transcr...
ORGANISM(S): Amphimedon queenslandica 
2012-07-10 | E-GEOD-29978 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human neural progenitor cells and neurons with DISC1 interruption
Purpose: Genetic and clinical association studies have identified disrupted-in-schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family, in which the translocation predisposes to psychiatric disorders. ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-71289 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
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