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SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
Effect of "Sensory Protection" on the transcriptome of Gastrocnemius muscle denervated by Tibial nerve transection in the rat. Comparison is made between the muscle transcriptome in denervated muscle (D), muscle undergoing surgical repair with a motor nerve (immediate repair, or IR) and muscle under...
ORGANISM(S): Rattus norvegicus 
The proper balance of excitatory and inhibitory neurons is crucial to normal processing of somatosensory information in the dorsal spinal cord. Two neural basic helix-loop-helix transcription factors, Ascl1 and Ptf1a, are essential for generating the correct number and sub-type of neurons in multipl...
ORGANISM(S): Mus musculus 
SUDHL4 SAMHD1 knockout cells were treated with 24uM gemcitabine for 1h and 8h (with 8h vehicle control), collected and subjected to CETSA heating, followed by cell lysis, isolation of soluble fraction and sample preparation for MS including digestion, desalting, TMT labeling, offline fractionation a...
ORGANISM(S): Homo Sapiens (human) 
SUDHL4 cells were treated with vehicle control, 24uM gemcitabine alone, DMSO, 6uM AZD6738 alone, or 24uM Gemcitabine with 6uM AZD6738 for 6h, collected and subjected to CETSA heating, followed by cell lysis, isolation of soluble fraction and sample preparation for MS including digestion, desalting, ...
ORGANISM(S): Homo Sapiens (human) 
Freshly isolated PBMCs from a R/R DLBCL patient were treated with increasing gemcitabine concentrations (and vehicle control) for 5h, collected and subjected to CETSA heating, followed by cell lysis, isolation of soluble fraction and sample preparation for MS including digestion, desalting, TMT labe...
ORGANISM(S): Homo Sapiens (human) 
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