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TranscriptomicsAtf1-mediated active gene response to H2O2 challenge.
Here we present the study on ChIP-chip mapping of the genomic binding sites for Sty1, Atf1, and the Atf1's binding partner Pcr1; the genome-wide transcriptional profiling of the atf1 and pcr1 strains in response to H2O2; and the phenotypic assessment of ~90 Atf1/Pcr1-bound or unbound genes for growt...
ORGANISM(S): Schizosaccharomyces pombe 
2010-07-19 | E-GEOD-13053 | biostudies-arrayexpress
TranscriptomicsGene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
ProteomicsComprehensive proteomic analysis reveals distinct features and diagnostic biomarker panel for early pregnancy loss in histological subtypes
Early pregnancy loss (EPL) is a common event in human reproduction and is classified into histological subtypes such as hydropic abortion (HA) and hydatidiform moles, including complete hydatidiform moles (CHMs) and partial hydatidiform moles (PHMs). However, accurate diagnosis and improved patient ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053739 | Pride
Proteomic Hydatidiform mole Early pregnancy loss Precious diagnosis Biomarkers 
ProteomicsComprehensive proteomic analysis reveals distinct features and diagnostic biomarker panel for early pregnancy loss in histological subtypes
Early pregnancy loss (EPL) is a common event in human reproduction and is classified into histological subtypes such as hydropic abortion (HA) and hydatidiform moles, including complete hydatidiform moles (CHMs) and partial hydatidiform moles (PHMs). However, accurate diagnosis and improved patient ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055182 | Pride
Proteomic Hydatidiform mole Early pregnancy loss Precious diagnosis Biomarkers 
TranscriptomicsTranscription profiling of mouse (SCID) after intestinal xenotransplants infected with Shigella
to analyse the transcriptomic response of human intestinal tissue engrafted in SCID mice to Shigella infection Experiment Overall Design: Four experimental conditions with two biological replicates. Experiment Overall Design: After 2 hours infection, tissues were removed and ARN were extracted befor...
ORGANISM(S): Homo sapiens 
2008-10-18 | E-GEOD-8636 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis rosette leaves
The focus of this study was to identify changes in host gene expression induced by the transcription-dependent function of the viral AC2 protein, and induced by the interaction of AC2/C2 with SnRK1.2 (AtAKIN11). We used microarrays to identify changes in host gene expression induced by the transcrip...
ORGANISM(S): Arabidopsis thaliana 
2014-10-09 | E-GEOD-62180 | biostudies-arrayexpress
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
TranscriptomicsThe genomic foundation of heterotrophy to photoautotrophy transition in Oleaginous Chlorella
The understanding of molecular events occurring in Chlorella during heterotrophy to photoautotrophy transition as well as sudden light stress and glucose starvation, are still largely unknown. To well grasp its cellular metabolism, particularly the regulation of biosynthesis and degradation pathways...
ORGANISM(S): Chlorella pyrenoidosa 
2015-11-02 | E-GEOD-40028 | biostudies-arrayexpress
TranscriptomicsThe Monocyte Advantage
INTRO: The ongoing challenge of accurately diagnosing infection in the ICU motivates a search for novel molecular diagnostics. In the current study, we tested the hypothesis that the informational content of circulating leukocytes differs, thereby allowing one to rank leukocyte populations on their ...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-GEOD-12838 | biostudies-arrayexpress
ProteomicsTMT-based LC-MS/MS proteomics of cholesteatoma
Eight cases of middle ear cholesteatoma specimens and matched ear canal skin specimens
ORGANISM(S): Homo Sapiens 
2023-03-07 | PXD036926 |
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