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TranscriptomicsCGH analysis of AG-haESCs (androgenetic haploid embryonic stem cells)
The genomic DNA sample of AG-haESCs were compared to the C57BL/6J male mouse kidney by comparative genomic hybridization. The data confirmed that the haploid cells sustained genome integrity. The analysis was performed on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array to analyse the copy num...
ORGANISM(S): Mus musculus 
2012-04-26 | E-GEOD-35786 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from AG-haESC, E14 and MEF
Haploid cells are amenable for genetic analysis because they contain only one set of chromosomes.Here,we report the derivation of haESCs from androgenetic blastocysts. These cells, which we designated AG-haESCs, express classical ESC markers, are pluripotent, and contribute to various tissues includ...
ORGANISM(S): Mus musculus 
2012-04-26 | E-GEOD-35785 | biostudies-arrayexpress
TranscriptomicsExpression data from Versican (VCAN) protein treated ovarian cancer cell line OVCA433
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Currently patients are treated by surgical cytoreductive surgery with the aim of reducing tumor burden to microscopic disease followed by adjuvant combined treatment with a platinum and taxane containing chemothe...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40241 | biostudies-arrayexpress
ProteomicsProteome sequencing of uterus at different eggshell strenghten and thickness of hens
In this study, we employed proteomics to investigate the differences between the uteruses of laying hens with high- or low-breaking-strength shells.
ORGANISM(S): Gallus Gallus 
2020-09-14 | PXD021449 |
TranscriptomicsThe Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus
Pre-mRNA splicing is regulated by developmental and environmental cues, but little is known about how specific signals are transduced in mammalian cells to regulate this critical gene expression step. Here, we report massive reprogramming of alternative splicing in response to EGF signaling. By blo...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-37731 | biostudies-arrayexpress
ProteomicsThe Glomerulus Multi-Omics Analysis Provides Deeper Insights into Diabetic Nephropathy
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD), however, the detail mechanisms remain unclear. Here, we integrated the transcriptomics and proteomics profiles of glomeruli isolated from 50 biopsy-proven DN patients and 25 controls to explore the new discoveries unde...
ORGANISM(S): Homo Sapiens 
2023-03-06 | PXD040617 |
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