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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsIdentification of lysine sites in RIG-I ubiquitinated by RNF167 through mass spectrometry analysis
To identify RNF167-catalyzed ubiquitinated peptides of RIG-I
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060570 | Pride
Lc-ms Ubiquitination 
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