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ProteomicsMetal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling
Systematically dissecting the highly dynamic and tightly communicating membrane proteome of living cells is essential for systems-level understanding of fundamental cellular processes and intricate relationship between membrane-bound organelles constructed through membrane traffic. While extensive e...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044945 | Pride
Membrane protein enrichment metal organic layers proteome 
ProteomicsAcetylome analysis of Botrytis cinerea
Lysine acetylation of proteins is a dynamic and reversible post-translational modification that plays an important role in diverse cellular processes. Botrytis cinerea is the most thoroughly studied necrotrophic species due to its broad host range and huge economic impact. However, to date, little i...
ORGANISM(S): Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) 
2017-11-02 | PXD004031 | Pride
Lysine acetylome Botrytis cinerea Immune-affinity purification Lc-ms/ms 
MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
ProteomicsLymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs
In the musculoskeletal system, lymphatic vessels (LVs), which are interdigitated with blood vessels, travel and form an extensive transport network. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, we investigated t...
ORGANISM(S): Rattus Norvegicus 
2024-10-05 | PXD056584 |
ProteomicsAffinity peptide ligands: New tools for chasing non-canonical N-phosphoproteome
Protein N-phosphorylation enrichment is faced with great difficulties due to the intrinsic instability of the N-P bond, which has seriously hindered its biological function unraveling. Current methods for N-phosphopeptides enrichment are challenging to fulfil high selectivity for all types of N-phos...
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus 
2024-12-12 | PXD058797 |
ProteomicsComprehensive Proteomic Profiling and Identification of Potential Hub Genes in Primary and Recurrent Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most lethal brain malignant neoplasm, associated with poor prognosis and high recurrence. The mechanisms involved in GBM development and recurrent remains largely unknown. Hence, it’s considerably imperative to explore the potential targets and unravel the mechan...
ORGANISM(S): Homo Sapiens 
2021-06-06 | PXD026503 |
ProteomicsDDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the foundi...
ORGANISM(S): Mus Musculus 
2024-03-13 | PXD050571 |
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