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MetabolomicsTire wear particles drive a systemic bioenergetic collapse in Eisenia fetida via coupled barrier erosion and metabolic-immune deadlock

As global vehicular electrification accelerates, the exponential accumulation of tire wear particles (TWPs) poses a pervasive threat to edaphic ecosystems. To elucidate the systemic bioenergetic impact of TWP toxicity, we performed a non-targeted metabolomic profiling of the soil sentinel earthwo...

2026-07-07 | MTBLS14967 | MetaboLights
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of pancreatic beta cells during maturation and with function-inactivating mutations
Islet β-cells from newborn mammals need a maturation process to become mature functional beta cells. The detailed molecular mechanisms were not completely understood. This study was designed to reveal the dynamic gene expression changes during pancreatic beta-cell maturation in postnatal mice. We al...
ORGANISM(S): Mus musculus 
2018-04-01 | E-MTAB-6615 | biostudies-arrayexpress
TranscriptomicsRegulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
Illumina Beadchip array analyses of mouse embryonic stem cell gene expression profiles in the presence of or upon knockdown of Aurka. An ES complementation 'rescue' system was employed to measure the effects of knockdown (minus Dox). Aurka was rescued to wildtype levels in the presence of Dox (plus ...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-23541 | biostudies-arrayexpress
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