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TranscriptomicsTranscription profiling of human T cell leukaemia cell line Jurkat that were retrovirally transduced with constitutievely active forms of Notch to identify novel transcriptional targets of Notch signalling
In this study we aimed to identify novel transcriptional targets of Notch signalling in the T cell leukaemia cell line, Jurkat. RNA was prepared from Jurkat cells retrovirally transduced with an empty vector (Mock) or vectors containing constitutively active forms of Notch (N1deltaE or N3deltaE), an...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-MEXP-1744 | biostudies-arrayexpress
GenomicsAltered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment
In the preimplantation mouse embryo TEAD4 is critical to establishing the trophectoderm (TE)-specific transcriptional program and segregating TE from the inner cell mass (ICM). However, TEAD4 is expressed both in the TE and the ICM. Thus, differential function of TEAD4 rather than expression itself ...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-37350 | biostudies-arrayexpress
UnknownHigh antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus.
Not available
S-EPMC9051606 | biostudies-literature
TranscriptomicsThe transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation
T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the formation of both terminal effector and memory precursor cells during infection. We find that at high concentrations T-bet induced expression of Zeb2 mRNA, which then trigg...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-72408 | biostudies-arrayexpress
ProteomicsAnother layer of complexity in Staphylococcus aureus methionine biosynthesis control: Unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
In Staphylococcus aureus, de novo methionine biosynthesis is regulated by a unique hierarchical pathway involving stringent-response controlled CodY repression in combination with a T-box riboswitch and RNA decay. The T-box riboswitch residing in the 5' untranslated region (met leader RNA) of the S....
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2021-08-10 | PXD020619 | Pride
Methionine biosynthesis Staphylococcus aureus Rna decay T-box riboswitch 
GenomicsIn vivo T-box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuro-mesodermal Bipotency.
We defined genome-wide regulatory inputs of the T-box transcription factors Brachyury (Xbra), Eomesodermin (Eomes) and VegT that maintain neuro-mesodermal stem cells and determine their bipotential fates in the Xenopus tropicalis frog embryo. Binding profiles for Xbra, Eomes and VegT in X. tropicali...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2013-09-19 | E-GEOD-48560 | biostudies-arrayexpress
UnknownA pressure-induced topological phase with large Berry curvature in Pb1-x Sn x Te.
Not available
S-EPMC5451193 | biostudies-literature
TranscriptomicsDe novo piRNA cluster formation in the Drosophila germline triggered by transgenes containing a transcribed transposon fragment
PIWI interacting RNAs (piRNAs) provide defense against transposable element (TE) expansion in the germline of metazoans. piRNAs are processed from the transcripts encoded by specialized heterochromatic clusters enriched in damaged copies of transposons. How these regions are recognized as a source o...
ORGANISM(S): Drosophila melanogaster 
2013-04-25 | E-GEOD-41780 | biostudies-arrayexpress
TranscriptomicsHigh-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridiz
We attempted to identify candidate genes that are expressed more highly in the ICM than in TE cells. Mouse ES cells are cultured from the ICM, whereas mouse TS cells are cultured from the TE. Although these cells have been cultured in vitro, they represent the in vitro equivalents of the ICM and TE....
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-3214 | biostudies-arrayexpress
TranscriptomicsCyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma
The authors previously suggested that CD204 was a useful marker for tumor-associated macrophages (TAMs) of esophageal squamous cell carcinoma (ESCC). In this study, they discovered that within ESCC microenvironment not only cancer cells but also TAMs expressed cysteine-rich, angiogenic inducer, 61 (...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-59471 | biostudies-arrayexpress
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