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ProteomicsMulti-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress
Background: Human bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine. Identifying key factors that regulate hBMSCs osteogenic differentiation is ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD067569 | Pride
Osteogenic differentiation Proteomics Bone marrow mesenchymal stromal cells Oxidative stress Transcriptomics 
TranscriptomicsMethylated DNA immunoprecipitation coupled with NimbleGen's array to identify methylated genes in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive cancer with a poor prognosis. Using methylated DNA immunoprecipitation (MeDIP)-chip analysis, we found that 161 genes that were specifically hypermethylated in PANC-1 cells. Among them, miR-615-5p was hypermethylated in its putative promot...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-44738 | biostudies-arrayexpress
TranscriptomicsIdentifying microRNA-mRNA regulatory networks in colorectal cancer by a combination of expression profile and bioinformatics analysis
A multi-step approach combining microarray profile and bioinformatics analysis was adopted to identify the CRC specific miRNA-mRNA regulatory network. First, differentially expressed miRNAs and mRNAs were found out in CRC samples compared with normal epithelial tissues by miRNA and mRNA microarray r...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-35982 | biostudies-arrayexpress
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