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TranscriptomicsCharacterization of human plasma-derived exosomal RNAs
Exosomes, endosome-derived membrane microvesicles, contain a specific set of RNA transcripts that are involved in cell-cell communication and hold a great potential as disease biomarkers. To systemically characterize exosomal RNA profiles, we performed RNA sequencing analysis using three human plasm...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-GEOD-45722 | biostudies-arrayexpress
TranscriptomicsCell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible interblastomere differences among ten 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differenc...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-57249 | biostudies-arrayexpress
ProteomicsSuccinylation profiles of brain injury after intracerebral hemorrhage
Protein posttranslational modifications (PTMs) has been shown to regulate biological processes of human diseases via expanding the genetic code and for regulating cellular pathophysiology, however, the system-wide changes at the PTMs levels in ICH brain remains little known. Given that succinylation...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-29 | PXD025621 | Pride
Intracerebral hemorrhage  brain injury  succinylation 
ProteomicsDeep Succinylproteomics of Brain Tissues of Intracerebral Hemorrhage with inhibition of Toll-like receptor 4 signaling
The details of Toll-like receptor (TLR) 4 signaling affects protein succinylation in intracerebral hemorrhage (ICH) brains remains completely unclear. In this study, we constructed mice ICH models to investigate the changes in ICH-associated brain protein succinylation with the treatment of TLR4 ant...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025622 | Pride
Intracerebral hemorrhage  brain injury  succinylation  toll-like receptor 4 
MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11844 | MetaboLights
MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11858 | MetaboLights
ProteomicsParabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity in Colon Cancer by Modulating CXCL10 and CD8+ T Cells
Outer membrane vesicles of Parabacteroides distasonis
ORGANISM(S): Parabacteroides Distasonis Atcc 8503 
2024-04-15 | PXD051464 |
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