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Genomicsde novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation
Cytosine methylation is an epigenetic mark usually associated with gene repression. Despite a requirement for de novo DNA methylation for differentiation of embryonic stem cells, its role in somatic stem cells is unknown. Using conditional ablation, we show that loss of either, or both, Dnmt3a or Dn...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-27322 | biostudies-arrayexpress
TranscriptomicsThe Atoh1 targetome in murine postnatal cerebellum
A relatively small number of proneural transcription factors specify a multitude of neural progenitor populations in the developing mammalian brain. Despite their importance, little is known about their targets, cellular processes they regulate, or what genomic sites they occupy in vivo. We used an ...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-22111 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29147 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [TKO]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29148 | biostudies-arrayexpress
GenomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29146 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Mus musculus 
2011-11-29 | E-GEOD-29150 | biostudies-arrayexpress
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